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Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk

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Abstract

Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the literature search in PubMed and Embase through October 2014 for all the potentially relevant studies. The odds ratios (ORs), together with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the strength of association. The search yielded eight studies (13 reports for rs2200733, 13 reports for rs10033464, and 7 reports for rs1906591). The ORs for overall ischemic stroke risk were 1.17 (95 % CI 1.09–1.26) for rs2200733*T, 1.02 (95 % CI 0.96–1.08) for rs10033464*T and 1.21 (95 % CI 1.10–1.32) for rs1906591*A. Stratified analysis by ischemic stroke subtypes revealed a stronger association between all the variants and cardioembolic stroke (CES) (OR = 1.41, 95 % CI 1.31–1.53 for rs2200733*T, OR = 1.18, 95 % CI 1.07–1.31 for rs10033464*T and OR = 1.51, 95 % CI 1.29–1.77 for rs1906591*A). The results of our meta-analysis indicated that chromosome 4q25 variants are associated with ischemic stroke risk, in particular cardioembolic stroke (CES).

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Abbreviations

OR:

Odds ratio

RR:

Relative risk

HR:

Hazard ratio

CI:

Confidence interval

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Conflict of Interests

The authors declare that they have no conflicts of interest.

Research Involving Human Participants and/or Animals

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Funding

This work was supported by the National Natural Science Foundation of China (31200938, 81220108008). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305# East Zhongshan Road, Nanjing, Jiangsu Province, China

    Lingli Sun, Zhizhong Zhang, Gelin Xu & Xinfeng Liu

  2. Molecular Oncology Research Institute, Tufts Medical Center, Tufts University, Boston, MA, USA

    Jian Xu

Authors
  1. Lingli Sun
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  2. Zhizhong Zhang
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  3. Jian Xu
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  4. Gelin Xu
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  5. Xinfeng Liu
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Correspondence to Zhizhong Zhang.

Electronic supplementary material

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Supplementary Table 1

(DOCX 17 kb)

Supplementary Table 2

(DOCX 16 kb)

Supplementary Fig. 1

Funnel plot of publication bias on the association between the variant rs2200733 and ischemic stroke risk. (DOCX 53 kb)

Supplementary Fig. 2

Funnel plot of publication bias on the association between the variant rs10033464 and ischemic stroke risk. (DOCX 50 kb)

Supplementary Fig. 3

Funnel plot of publication bias on the association between the variant rs1906591 and ischemic stroke risk. (DOCX 51 kb)

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Sun, L., Zhang, Z., Xu, J. et al. Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk. Mol Neurobiol 53, 3882–3890 (2016). https://doi.org/10.1007/s12035-015-9332-x

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  • DOI: https://doi.org/10.1007/s12035-015-9332-x

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