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Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke

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Abstract

Previous studies assessing the association between serum uric acid levels and neurological outcome after acute ischemic stroke reported conflicting results. A systematic review and meta-analysis were conducted to assess the impact of serum uric acid levels on outcome after acute ischemic stroke. Pubmed, Embase, Web of Science, and Google scholar were searched through September 26, 2014 to identify eligible published or unpublished studies on the association between serum uric acid levels and outcome after acute ischemic stroke. Hazard ratio (HR) for poor outcome or mean differences of serum uric acid levels with 95 % confidence intervals (95 % CIs) were pooled using meta-analysis. The primary outcome was occurrence of poor outcomes, while the secondary outcome was the mean differences of serum uric acid levels in patients with good or poor outcomes. Ten eligible studies with a total of 8131 acute ischemic stroke patients were included into the meta-analysis. Compared with low serum uric acid level, high serum uric acid level was associated better outcome after acute ischemic stroke (HR = 0.77, 95 % CI 0.68–0.88, P = 0.0001). Sensitivity analysis further identified the prognostic role of serum uric acid levels on outcome after acute ischemic stroke. Patients with good outcomes had a higher serum uric acid level compared with those with poor outcome (mean difference = 30.61 μmol/L, 95 % CI 20.13–41.08, P < 0.00001). There was no obvious risk of publication bias in the meta-analysis. This meta-analysis supports that serum uric acid level has a protective effect on neurological outcome after acute ischemic stroke. High uric acid level at the onset is a biomarker of better prognosis in patients with acute ischemic stroke.

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Compliance with Ethical Standards

There was no funding for the study. The present study was a meta-analysis, which did not involve human participants and/or animals. In addition, no informed consent was needed in the meta-analysis.

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    Authors and Affiliations

    1. Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China

      Zhongchao Wang, Yanlin Lin, Ying Chen, Bin Wang, Shengli Yan, Yangang Wang & Wenjuan Zhao

    2. Shandong Provincial Key Laboratory of Metabolic Disease, Affiliated Hospital of Qingdao University, Qingdao, 266003, China

      Yuxiu Liu & Changgui Li

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    1. Zhongchao Wang
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    Correspondence to Yangang Wang or Wenjuan Zhao.

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    Zhongchao Wang, Yuxiu Liu and Ying Chen contributed equally to this work.

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    Wang, Z., Lin, Y., Liu, Y. et al. Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke. Mol Neurobiol 53, 1753–1759 (2016). https://doi.org/10.1007/s12035-015-9134-1

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