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CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations

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Abstract

Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer’s disease (AD) in Caucasian ancestry. Both rs11136000 and rs2279590 variants were successfully replicated in Asian population. However, previous studies reported either a weak association or no association between rs9331888 polymorphism and AD in Asian population. Here, we searched the PubMed, AlzGene, and Google Scholar databases. We selected 12 independent studies that evaluated the association between the rs9331888 polymorphism and AD using a case-control design. Using an additive model, we did not identify significant heterogeneity among these 12 studies. We observed significant association between rs9331888 polymorphism and AD in pooled populations (P = 2.26E − 07, odds ratio (OR) = 1.10, 95 % confidence interval (CI) 1.06–1.14). In subgroup analysis, we did not identify significant heterogeneity in both Asian and Caucasian populations. We identified significant association in Caucasian population (P = 1.67E − 08, OR = 1.13, 95 % CI 1.08–1.18) but not in East Asian population (P = 0.49, OR = 1.02, 95 % CI 0.96–1.10).

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Acknowledgments

This work was supported by funding from the National Nature Science Foundation of China (Grant Nos. 81300945, 31200934, 31301938, 81471294, 31171219, 81271213, and 81271214) and Harbin Science and Technology Bureau (2014RFXGJ042).

Conflict of Interest

The authors declare no conflict of interest.

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    Authors and Affiliations

    1. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China

      Shuyan Zhang & Xuling Li

    2. Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China

      Guoda Ma, Bin Zhao & Keshen Li

    3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

      Yongshuai Jiang

    4. College of Life Science, Northwest A&F University, Yangling, Shaanxi, China

      Mingzhi Liao

    5. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China

      Rennan Feng

    6. Department of Statistics, Rice University, Houston, TX, USA

      Liangcai Zhang

    7. Department of Neurology, The First Hospital of Harbin, Harbin, China

      Jiafeng Liu

    8. Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China

      Guangyu Wang

    9. School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China

      Qinghua Jiang

    10. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China

      Guiyou Liu

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    1. Shuyan Zhang
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    Correspondence to Qinghua Jiang, Keshen Li or Guiyou Liu.

    Additional information

    Shuyan Zhang, Xuling Li and Guoda Ma contributed equally to this work.

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    Zhang, S., Li, X., Ma, G. et al. CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations. Mol Neurobiol 53, 1446–1451 (2016). https://doi.org/10.1007/s12035-015-9098-1

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