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Targeting IL-10 in Auto-immune Diseases

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Abstract

IL-10 is a multifunctional cytokine secreted by a variety of cells. It not only inhibits activation of monocyte/macrophage system and synthesis of monocyte cytokine and inflammatory cytokine but also promotes the proliferation and maturation of non-monocyte-dependent T cell, stimulating proliferation of antigen-specific B cell. Increasing evidence indicates that IL-10 plays an important role in both the onset and development of auto-immune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren’s syndrome (SS), multiple sclerosis (MS), Crohn’s disease (CD), and psoriasis. However, the exact mechanisms of IL-10 in auto-immune diseases remain unclear. In the present review, we will summarize the biological effects of IL-10, as well as its role and therapeutic potential in auto-immune diseases.

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Authors and Affiliations

  1. School of Health Management, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China

    Guo Tian, Jiao-Long Li & Dian Zhou

  2. Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

    De-Guang Wang

  3. The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China

    Dian Zhou

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Tian, G., Li, JL., Wang, DG. et al. Targeting IL-10 in Auto-immune Diseases. Cell Biochem Biophys 70, 37–49 (2014). https://doi.org/10.1007/s12013-014-9903-x

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