Abstract
The cytokine-inducible SRC homology 2 domain (CISH) gene is up-regulated by IL-2 in response to infection, and inhibits microbial infection. The objective of the present study was to examine whether genetic variants of CISH (SNPs) are associated with increased susceptibility to tuberculosis (TB) in individuals of Chinese Han ethnicity. We sequenced five previously identified SNPs of CISH in patients with TB or healthy controls. Three of the SNPs, rs148685070 [position −639; C/C], rs414171 [position −292; A/T], and rs6768300 [position −163; C/G]) are located in the promoter region, while the fourth (rs2239751 [position +1320; A/C]) near the translation start site, and the fifth (rs622502 [position +3415; C/G]) in the third intron. The AA genotypes of the SNPs rs2239751 and rs414171 were significantly associated with TB. Multivariate logistic regression analysis demonstrated that subjects with the rs414171 AA genotype were more likely to have TB than those with the AT genotype. By contrast, we did not observe genetic variants of the rs148685070 SNP. In conclusion, two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population.
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Abbreviations
- CISH:
-
Cytokine-inducible SRC homology 2 (SH2) domain protein
- IL-2:
-
Interleukin-2
- TB:
-
Tuberculosis
- SH2:
-
SRC homology 2
- SNP:
-
Single-nucleotide polymorphism
- STAT5:
-
Signal transducer and activator of transcription 5
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The authors are thankful for all great help provided by the Bacteria Department of Shanghai Pulmonary Hospital.
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Lan Zhao and Haiqing Chu contributed equally to this paper and should be considered co-first authors.
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Zhao, L., Chu, H., Xu, X. et al. Association Between Single-Nucleotide Polymorphism in CISH Gene and Susceptibility to Tuberculosis in Chinese Han Population. Cell Biochem Biophys 68, 529–534 (2014). https://doi.org/10.1007/s12013-013-9733-2
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DOI: https://doi.org/10.1007/s12013-013-9733-2