Abstract
The aim of this study is to evaluate the differences of left ventricular (LV) twist and untwisting rate in patients with acute myocardial infarction (AMI) as compared with healthy subjects by means of Speckle Tracking Imaging (STI). 45 AMI patients (AMI group) and 48 healthy subjects (NOR group) were studied. Two-dimensional STI was performed in all patients. Peak apical rotation, peak basal rotation, peak LV twist, peak basal untwisting rate, peak apical untwisting rate, peak LV untwisting rate, time to peak LV twist, and untwisting rate were measured. In comparison with the NOR group, peak LV rotational parameters were found to be decreased in the AMI group (P < 0.01). A strong correlation was found between the peak LV twist and LV ejection fraction in the overall study population (P < 0.001). The LV twist is strongly related to LV systolic function, and the impairment of LV function observed in patients with AMI is associated with a decrease of LV twist and untwist rate. The STI appears to accurately evaluate LV function.
Similar content being viewed by others
References
Harvey, W. (1941). An anatomical disposition on the motion of the heart and blood in animals. In F. Willis & T. Keys (Eds.), Cardiac classics (pp. 19–79). London: Henry Kimpton.
Yun, K. L., Niczyporuk, M. A., Daughters, G. T., II, Ingels, N. B., Jr., Stinson, E. B., et al. (1991). Alterations in left ventricular diastolic twist mechanics during acute human cardiac allograft rejection. Circulation, 83, 962–973.
Rademakers, F. E., Buchalter, M. B., Rogers, W. J., Zerhouni, E. A., Weisfeldt, M. L., et al. (1992). Dissociation between left ventricular untwisting and filling. Accentuation by catecholamines. Circulation, 85, 1572–1581.
Stuber, M., Scheidegger, M. B., Fischer, S. E., Nagel, E., Steinemann, F., et al. (1999). Alterations in the local myocardial motion pattern in patients suffering from pressure overload due to aortic stenosis. Circulation, 100, 361–368.
Corno, A. F., Kocica, M. J., & Torrent-Guasp, F. (2006). The helical ventricular myocardial band of Torrent-Guasp: Potential implications in congenital heart defects. European Journal of Cardio-Thoracic Surgery, 29(Suppl 1), S61–S68.
Burns, A. T., McDonald, I. G., Thomas, J. D., Macisaac, A., & Prior, D. (2008). Doin’ the twist: New tools for an old concept of myocardial function. Heart, 94, 978–983.
Takeuchi, M., Nakai, H., Kokumai, M., Nishikage, T., Otani, S., et al. (2006). Age-related changes in left ventricular twist assessed by two-dimensional speckle-tracking imaging. Journal of the American Society of Echocardiography, 19, 1077–1084.
Notomi, Y., Martin-Miklovic, M. G., Oryszak, S. J., Shiota, T., Deserranno, D., et al. (2006). Enhanced ventricular untwisting during exercise: A mechanistic manifestation of elastic recoil described by Doppler tissue imaging. Circulation, 113, 2524–2533.
Galderisi, M., Lomoriello, V. S., Santoro, A., Esposito, R., Olibet, M., et al. (2010). Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: A speckle-tracking echocardiography study. Journal of the American Society of Echocardiography, 23, 1190–1198.
Quinones, M. A., Otto, C. M., Stoddard, M., Waggoner, A., & Zoghbi, W. A. (2002). Recommendations for quantification of Doppler echocardiography: A report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. Journal of the American Society of Echocardiography, 15, 167–184.
Puwanant, S., Park, M., Popovic, Z. B., Tang, W. H., Farha, S., et al. (2010). Ventricular geometry, strain, and rotational mechanics in pulmonary hypertension. Circulation, 121, 259–266.
Foster, E., & Lease, K. E. (2006). New untwist on diastole: What goes around comes back. Circulation, 113, 2477–2479.
Mailloux, G. E., Bleau, A., Bertrand, M., & Petitclerc, R. (1987). Computer analysis of heart motion from two-dimensional echocardiograms. IEEE Trans Biomed Eng, 34, 356–364.
Arts, T., Veenstra, P. C., & Reneman, R. S. (1982). Epicardial deformation and left ventricular wall mechanisms during ejection in the dog. American Journal of Physiology, 243, H379–H390.
Sengupta, P. P., Khandheria, B. K., Korinek, J., Wang, J., & Belohlavek, M. (2005). Biphasic tissue Doppler waveforms during isovolumic phases are associated with asynchronous deformation of subendocardial and subepicardial layers. Journal of Applied Physiology, 99, 1104–1111.
Lorenz, C. H., Pastorek, J. S., & Bundy, J. M. (2000). Delineation of normal human left ventricular twist throughout systole by tagged cine magnetic resonance imaging. Journal of Cardiovascular Magnetic Resonance, 2, 97–108.
Henson, R. E., Song, S. K., Pastorek, J. S., Ackerman, J. J., & Lorenz, C. H. (2000). Left ventricular torsion is equal in mice and humans. American Journal of Physiology Heart and Circulatory Physiology, 278, H1117–H1123.
McDonald, I. G. (1970). The shape and movements of the human left ventricle during systole. A study by cineangiography and by cineradiography of epicardial markers. American Journal of Cardiology, 26, 221–230.
Helle-Valle, T., Crosby, J., Edvardsen, T., Lyseggen, E., Amundsen, B. H., et al. (2005). New noninvasive method for assessment of left ventricular rotation: Speckle tracking echocardiography. Circulation, 112, 3149–3156.
Notomi, Y., Lysyansky, P., Setser, R. M., Shiota, T., Popovic, Z. B., et al. (2005). Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. Journal of the American College of Cardiology, 45, 2034–2041.
Goffinet, C., Chenot, F., Robert, A., Pouleur, A. C., de Waroux, J. B., et al. (2009). Assessment of subendocardial vs. subepicardial left ventricular rotation and twist using two-dimensional speckle tracking echocardiography: Comparison with tagged cardiac magnetic resonance. European Heart Journal, 30, 608–617.
Opdahl, A., Helle-Valle, T., Remme, E. W., Vartdal, T., Pettersen, E., et al. (2008). Apical rotation by speckle tracking echocardiography: A simplified bedside index of left ventricular twist. Journal of the American Society of Echocardiography, 21, 1121–1128.
Beyar, R., & Sideman, S. (1986). Left ventricular mechanics related to the local distribution of oxygen demand throughout the wall. Circulation Research, 58, 664–677.
D’ Hooge, J., Claus, P., & Separovic, J. (2002). Alterations of systolic left ventricular twist after acute myocardial infarction. American Journal of Physiology Heart Circulatory Physiology, 283, H2733–H2734.
Bansal, M., Leano, R. L., & Marwick, T. H. (2008). Clinical assessment of left ventricular systolic torsion: Effects of myocardial infarction and ischemia. Journal of the American Society of Echocardiography, 21, 887–894.
Sun, J. P., Niu, J., Chou, D., Chuang, H. H., Wang, K., et al. (2007). Alterations of regional myocardial function in a swine model of myocardial infarction assessed by echocardiographic 2-dimensional strain imaging. Journal of the American Society of Echocardiography, 20, 498–504.
Bertini, M., Delgado, V., Nucifora, G., Ajmone Marsan, N., Ng, A. C., et al. (2010). Left ventricular rotational mechanics in patients with coronary artery disease: Differences in subendocardial and subepicardial layers. Heart, 96, 1737–1743.
Knudtson, M. L., Galbraith, P. D., Hildebrand, K. L., Tyberg, J. V., & Beyar, R. (1997). Dynamics of left ventricular apex rotation during angioplasty: A sensitive index of ischemic dysfunction. Circulation, 96, 801–808.
Garot, J., Pascal, O., Diebold, B., Derumeaux, G., Gerber, B. L., et al. (2002). Alterations of systolic left ventricular twist after acute myocardial infarction. American Journal of Physiology Heart and Circulatory Physiology, 282, H357–H362.
Notomi, Y., Popovic, Z. B., Yamada, H., Wallick, D. W., Martin, M. G., et al. (2008). Ventricular untwisting: A temporal link between left ventricular relaxation and suction. American Journal of Physiology Heart and Circulatory Physiology, 294, H505–H513.
Acknowledgment
This study was supported by a Science and Technology Research Grant of Liaoning Provincial Department of Education (Grant No. 2008748) to DJ.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jia, Dl., Ma, Cy., Liu, S. et al. Evaluation of Left Ventricular Twist in Acute Myocardial Infarction Patients Using Speckle Tracking Imaging. Cell Biochem Biophys 61, 673–678 (2011). https://doi.org/10.1007/s12013-011-9223-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12013-011-9223-3