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Ameliorative Potential of Prepartal Trace Mineral and Vitamin Supplementation on Parturition-Induced Redox Balance and Myeloperoxidase Activity of Periparturient Sahiwal Cows

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Abstract

Twelve apparently healthy multiparous parturient Sahiwal cows were allocated into two groups having six cows in each one. Six cows were supplemented with antioxidant mixture (mixture containing Cu, Mn, Cr, Zn, and vitamins A and D3) daily from 21 days before parturition till the day relative to calving. Whereas, remaining non-supplemented six cows were kept as the control group. Blood samples were obtained five times: at enrolment (21 days pre-partum), and again at days 0, +7, +14, and +21 relative to calving. In the non-supplemented control group, serum total antioxidant capacity (TAC) was significantly lower at days 0, +7, and +14 as compared to their own day −21 values. Likewise, significantly lower myeloperoxidase (MPO) activities were also exhibited by these cows at days 0 and +7. Conversely, serum malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly higher in these cows at days 0, +7, +14, and +21. However, significant alterations in TAC content among the studied sampling days were not recorded in antioxidants supplemented group. Moreover, TAC content and MPO activities of supplemented group were significantly higher at days 0, +7, and +14 when compared with that of the non-supplemented control group. However, MDA and PC contents of supplemented group were significantly lower at days 0, +7, +14, and +21 as compared to that of the non-supplemented control group. In conclusion, periparturient Sahiwal cows experience substantial oxidative and immunological dents which can be potentially ameliorated by prepartal trace mineral and vitamin supplementation.

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Acknowledgments

The authors are thankful to the Vice Chancellor, DUVASU, for the facilities and financial assistance provided.

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Authors and Affiliations

  1. Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India

    Brajesh K. Yadav, Shanker K. Singh, Vivek K. Singh & Mukesh Srivastava

  2. Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India

    Udayraj P. Nakade, Abhishek Sharma & Satish K. Garg

  3. Departmet of Physiology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India

    Brijesh Yadav

  4. Department of Livestock Production and Management, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, U.P, 281 001, India

    Yajuvendra Singh & Rajneesh Sirohi

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  1. Brajesh K. Yadav
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  2. Shanker K. Singh
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Correspondence to Shanker K. Singh.

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Ethical Approval

The study was in accordance with the ethical standards of the Local Ethics Committee on Animal Experimentation of U.P. Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura, India.

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Yadav, B.K., Singh, S.K., Nakade, U.P. et al. Ameliorative Potential of Prepartal Trace Mineral and Vitamin Supplementation on Parturition-Induced Redox Balance and Myeloperoxidase Activity of Periparturient Sahiwal Cows. Biol Trace Elem Res 177, 72–79 (2017). https://doi.org/10.1007/s12011-016-0864-3

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