Abstract
The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n = 59) and case (obese women, n = 55). The analysis of magnesium intake was carried out through the 3-day food record and also NutWin software version 1.5. The plasma, erythrocyte, and urinary magnesium concentrations were determined by flame atomic absorption spectrophotometry. The determinations of serum glucose and serum insulin were performed by enzymatic colorimetric method and chemiluminescence, respectively. The insulin resistance was assessed by homeostasis model assessment insulin resistance (HOMA-IR). The mean values of magnesium intake were lower than those recommended, without difference between groups (p > 0.05). All the patients who were evaluated showed adequate mean concentrations of magnesium in the plasma and erythrocyte. The urinary excretion of this mineral was lower than the reference values in both groups and did not show significant difference (p > 0.05). The values of serum glucose, serum insulin, and HOMA-IR were higher in obese women compared to the control group. A negative correlation was observed between erythrocyte magnesium and glycemic parameters (p < 0.05). Obese patients take in foods with low dietary magnesium content, and they show hypomagnesuria as a compensatory mechanism to keep the plasma concentration of this mineral in adequate levels. The correlation between the erythrocyte magnesium concentration and the parameters of glycemic control suggests the influence of this mineral on the index of insulin resistance in obese women.
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Acknowledgments
The authors thank Professor Dr. José Machado Moita Neto for his contribution in the analysis and interpretation of statistical data.
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The authors declare that they have no conflict of interest.
Ethical Standards
The study was approved by Research Ethics Committee of the Federal University of Piaui, protocol number 13489613.5.0000.5214, and conducted in accordance with the Declaration of Helsinki. All patients signed a consent form.
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Cruz, K.J.C., de Oliveira, A.R.S., Pinto, D.P. et al. Influence of Magnesium on Insulin Resistance in Obese Women. Biol Trace Elem Res 160, 305–310 (2014). https://doi.org/10.1007/s12011-014-0044-2
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DOI: https://doi.org/10.1007/s12011-014-0044-2