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The effect of black seed raisin on some cardiovascular risk factors, serum malondialdehyde, and total antioxidant capacity in hyperlipidemic patients: a randomized controlled trials

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Abstract

Background

The lipid-lowering properties and antioxidants of the raisins may reduce the risk factors of cardiovascular diseases. This study aimed to investigate the effect of black seeded raisin consumption on blood pressure (BP), lipid profile, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and serum total antioxidant capacity (TAC) in hyperlipidemic patients.

Methods

Thirty-eight hyperlipidemic patients aged 41.05 ± 10.4 years were recruited to this two-armed, randomized, controlled intervention trial. Participants were instructed to consume 90 g per day black seed raisin in the intervention group, and control group received no intervention. BP, lipid profile, and plasma levels of TAC, MDA, hs-CRP, and FBS were determined at baseline and week 5.

Results

After 5 weeks, the diastolic BP reduced significantly in raisin group compared with baseline (81.80 ± 10.22 vs 77.05 ± 11.03, P = 0.001) and TAC was significantly increased in raisin group compared with the control group (394 ± 116.93 vs 479 ± 122.31, P = 0.001). The serum level of MDA in the raisin group was significantly lower compared with the control group (1.35 ± 0.88 vs 1.39 ± 0.67, P = 0.039). No significant changes were found in lipid profile, SBP, hs-CRP, and FBS.

Conclusion

These results suggest that consumption of black raisin which is rich in polyphenolic compounds has beneficial effects on some cardiovascular risk factors especially blood pressure and serum antioxidant capacity in patients with hyperlipidemia.

Trial registration

Trial registration number: IRCT2015091624049N1. This study was registered in the Iranian Registry of Clinical Trials (IRCT). URL of trial registry record: https://www.irct.ir/trial/20395

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Availability of data and material

All data will be made available upon request.

Abbreviations

BP:

Blood pressure

hs-CRP:

Lipid profile, high-sensitivity C-reactive protein

MDA:

Malondialdehyde

TAC:

Serum total antioxidant capacity

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Acknowledgements

Authors would like to thank all volunteers who participated in the study. The current study was a part of the master thesis of Parvin Joola. The vice chancellor for research affaire of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, supported the current study (grant number: NRC-9404).

Funding

Funding for this study was provided by Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Author information

Authors and Affiliations

  1. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Farideh Shishehbor

  2. Department of Nutrition, Para-Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Parvin Joola

  3. Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Amal Saki Malehi

  4. Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mohammad Ali Jalalifar

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  1. Farideh Shishehbor
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  2. Parvin Joola
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  3. Amal Saki Malehi
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  4. Mohammad Ali Jalalifar
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Contributions

FSH, PJ, and ASM designed the study and involved in the data collection, analysis, and drafting of the manuscript. PJ and MAJ were involved in the design of the study, analysis of the data, and critically reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Parvin Joola.

Ethics declarations

Ethics approval and consent to participate

This study was approved by Research Ethics Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (code 1394.103REC IR.AJUMS), and registered in IRCT clinical trial database (code N1 2015091624049). Furthermore, the necessary details of the project were explained clearly to the patients or their first-degree relatives, and written informed consent was obtained from them before they joined the study.

Competing interests

The authors declare that they have no competing interests.

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Shishehbor, F., Joola, P., Malehi, A.S. et al. The effect of black seed raisin on some cardiovascular risk factors, serum malondialdehyde, and total antioxidant capacity in hyperlipidemic patients: a randomized controlled trials. Ir J Med Sci 191, 195–204 (2022). https://doi.org/10.1007/s11845-021-02566-7

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  • DOI: https://doi.org/10.1007/s11845-021-02566-7

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