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Inhibition control impairments in adolescent smokers: electrophysiological evidence from a Go/NoGo study

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Abstract

Smoking during adolescence may promote nicotine dependence later on in life. Therefore, it is extremely important to study the neural mechanisms of adolescent smokers. As inhibition control is emphasized in several contemporary theoretical models of addiction, in the current study, we focused on the electrophysiological evidence of inhibition control deficits in adolescent smokers. By using relatively homogenous groups of adolescent smokers (n = 18) and matched nonsmokers (n = 18), we employed event-related potentials (ERP) to investigate the N200 and P300 amplitude and latency differences during a Go/NoGo task between the adolescent smokers and nonsmokers. Relative to nonsmokers, more NoGo response errors, reduced NoGo P300 amplitude, and longer P300 latency were observed in adolescent smokers. Correlation analysis revealed that the NoGo P300 amplitudes were significantly correlated with NoGo errors in both adolescent smokers and nonsmokers. Our findings provided direct electrophysiological evidence for inhibitory control impairments in adolescent smokers. It is hoped that our results may enhance understanding of the pathology of inhibitory control in adolescent smokers.

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Acknowledgments

This paper is supported by the Project for the National Key Basic Research and Development Program (973) under Grant nos. 2014CB543203, 2011CB707700, 2012CB518501, the National Natural Science Foundation of China under Grant nos. 81401478, 81401488, 81271644, 81271546, 81271549, 81470816, 81471737, 81301281, the Natural Science Basic Research Plan in Shaanxi Province of China under Grant no. 2014JQ4118, and the Fundamental Research Funds for the Central Universities under the Grant nos. 8002–72135767, 8002–72145760, the Natural Science Foundation of Inner Mongolia under Grant no. 2012MS0908. General Financial Grant the China Post- doctoral Science Foundation under Grant no. 2014 M552416.

Conflict of Interest

Junsen Yin, Kai Yuan, Dan Feng, Jiadong Cheng, Yangding Li, Chenxi Cai, Yanzhi Bi, Shi Sha, Xiaomin Shen, Ben Zhang, Ting Xue, Wei Qin, Dahua Yu, Xiaoqi Lu, and Jie Tian declare that they have no conflicts of interest.

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Authors and Affiliations

  1. School of Life Science and Technology, Xidian University, Xi’an Shaanxi, 710071, People’s Republic of China

    Junsen Yin, Kai Yuan, Dan Feng, Jiadong Cheng, Yangding Li, Chenxi Cai, Yanzhi Bi, Shi Sha, Xiaomin Shen, Wei Qin & Jie Tian

  2. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi’an, People’s Republic of China

    Junsen Yin, Kai Yuan, Dan Feng, Jiadong Cheng, Yangding Li, Chenxi Cai, Yanzhi Bi, Shi Sha, Xiaomin Shen, Wei Qin & Jie Tian

  3. Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People’s Republic of China

    Kai Yuan, Ting Xue, Dahua Yu & Xiaoqi Lu

  4. School of Mechanical, Sanjiang University, Nanjing, Jiangsu, 210012, People’s Republic of China

    Ben Zhang

  5. Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People’s Republic of China

    Jie Tian

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  1. Junsen Yin
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Yin, J., Yuan, K., Feng, D. et al. Inhibition control impairments in adolescent smokers: electrophysiological evidence from a Go/NoGo study. Brain Imaging and Behavior 10, 497–505 (2016). https://doi.org/10.1007/s11682-015-9418-0

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