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Intrahepatic cholestasis of pregnancy: Biochemical predictors of adverse perinatal outcomes

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Summary

This study aimed to identify biochemical predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP). A total of 106 ICP cases were analyzed retrospectively by the combination of receiver operating characteristic curve and binary logistic regression analysis. “Adverse perinatal outcomes” included spontaneous preterm labor, meconium-staining of amniotic fluid, stillbirth and Apgar score ≤7 at 1 or 5 min. Total bile acid (TBA) [AUC=0.658, 95%CI (0.536, 0.781), P=0.031] was a valuable predictor for adverse perinatal outcomes. The critical value of TBA above which adverse perinatal outcomes were observed was 40.15 μmol/L (Youden’s index=0.3). Binary multivariate logistic regression analysis revealed that the risk of adverse perinatal outcomes increased when TBA ≥40.15 μmol/L [OR=3.792, 95%CI (1.226, 11.727), P=0.021]. It is concluded that the risk of adverse perinatal outcomes in ICP increases when maternal TBA ≥40.15 μmol/L.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Hui Chen  (陈 慧), Yuan Zhou  (周 媛), Dong-rui Deng  (邓东锐), Hai-yan Hao  (郝海燕), Jing Dang  (党 静) & Jing Li  (李 静)

  2. Department of Obstetrics, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China

    Hui Chen  (陈 慧)

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  1. Hui Chen  (陈 慧)
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  2. Yuan Zhou  (周 媛)
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  3. Dong-rui Deng  (邓东锐)
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  4. Hai-yan Hao  (郝海燕)
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  5. Jing Dang  (党 静)
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  6. Jing Li  (李 静)
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Correspondence to Dong-rui Deng  (邓东锐).

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These authors contributed equally to this work.

This project was supported by grants from the National Natural Science Foundation of China (Nos. 30973205, 81172464)

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Chen, H., Zhou, Y., Deng, Dr. et al. Intrahepatic cholestasis of pregnancy: Biochemical predictors of adverse perinatal outcomes. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 33, 412–417 (2013). https://doi.org/10.1007/s11596-013-1133-8

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  • DOI: https://doi.org/10.1007/s11596-013-1133-8

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