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A meta-analysis of the biomarkers associated with coronary artery lesions secondary to Kawasaki disease in Chinese children

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Summary

The biomarkers associated with coronary artery lesions (CAL) secondary to Kawasaki disease (KD) in Chinese children were investigated by using Meta-analysis. We searched documents published from January 1997 to December 2009 from medical electronic databases. According to inclusion and exclusion criteria, eligible full-text papers were identified. We conducted a comprehensive quantitative analysis by using Stata10.0 statistical software package to assess the heterogeneity among the documents, calculated the summary effect and analyze publication bias and sensitivity. A total of 92 documents and 16 biomarkers were identified. All documents were case-control studies, and included 2398 patients in CAL group and 5932 patients in non-CAL (NCAL) group. The Meta-analysis showed that the levels of platelet count, platelet hematocrit (PCT), neutrophils count, platelet distribution width (PDW), mean platelet volume (MPV), erythrocyte sedimentation rate (ESR), cardiac troponin I (cTnI), and endothelin-1 (ET-1) in CAL group were significantly higher than those in NCAL group, and serum albumin (Alb) and hemoglobin (Hb) levels were significantly lower in CAL group (all P<0.05). White blood cell (WBC) count, serum sodium, matrix metalloproteinase 9 (MMP-9), total cholesterol (TC), hematocrit (HCT) and CD3+T lymphocytes percentage had no statistically significant difference between the two groups. In conclusion, our results indicated that the 10 biomarkers including platelet count, neutrophils count, PCT, PDW, MPV, ESR, cTnI, ET-1, Alb and Hb were associated with CAL, and may be involved in the pathogenesis of CAL. The biomarkers of WBC count, serum sodium, MMP-9, TC, HCT, and CD3+T lymphocytes percentage bore no relationship with the development of CAL among Chinese children with KD.

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References

  1. Rowley AH, Shulman ST. Pathogenesis and management of Kawasaki disease. Expert Rev Anti Infect Ther, 2010,8(2):197–203

    Article  PubMed  Google Scholar 

  2. Burns JC, Glode MP. Kawasaki syndrome. Lancet, 2004,364(9433):533–544

    Article  PubMed  Google Scholar 

  3. Newburger JW, Fulton DR. Kawasaki disease. Curr Opin Pediatr, 2004,16(5):508–514

    Article  PubMed  Google Scholar 

  4. Iemura M, Ishii M, Sugirnura T, et al. Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function. Heart, 2000,83(3):307–311

    Article  PubMed  CAS  Google Scholar 

  5. Fukazawa R, Ogawa S. Long-term prognosis of patients with Kawasaki disease: at risk for future atherosclerosis? J Nippon Med Sch, 2009,76(3):124–133

    Article  Google Scholar 

  6. Harada K. Intravenous gamma-globulin treatment in Kawasaki disease. Acta Paediatr Jpn, 1991,33(6):805–810

    PubMed  CAS  Google Scholar 

  7. In: Wu Ruiping, Hu Yamei, Jiang Zaifang, eds. Zhu Futang applied pediatrics. 7th ed. Beijing: People’s Medical Publishing House, 2002,698–740

    Google Scholar 

  8. Kobayashi T, Inoue Y, Takeuchi K, et al. Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease. Circulation, 2006,113(22):2606–2612

    Article  PubMed  Google Scholar 

  9. Chen JJ, Huang M, Xie LJ, et al. Study on risky factors of the coronary artery lesion in Kawasaki disease (Chinese). J Clin Pediatr, 2009,27(5):442–445

    CAS  Google Scholar 

  10. Glass, GV. Primary, secondary, and Meta-analysis of research. Educ Res, 1976,5(10):3–8

    Google Scholar 

  11. Ayusawa M, Sonobe T, Uemura S, et al. Kawasaki Disease Research Committee. Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition). Pediatr Int, 2005,47(2):232–234

    Article  PubMed  Google Scholar 

  12. Research Committee on Kawasaki Disease. Report of Subcommittee on Standardization of Diagnostic Criteria and Reporting of Coronary Artery Lesions in Kawasaki Disease. Tokyo, Japan, Ministry of Health and Welfare, 1984

    Google Scholar 

  13. Lichtenstein MJ, Mulrow CD, Elwood PC. Guidelines for reading case-control studies. J Chronic Dis, 1987,40(9): 893

    Article  PubMed  CAS  Google Scholar 

  14. Eue I, Konig S, Pior J, et al. S100A8, S100A9 and the S100A8/A9 heterodimer complex specifically bind to human endothelial cells: identification and characterization of ligands for the myeloid-related proteins S100A9 and S100A8/A9 on human dermal microvascular endothelial cell line-1 cells. Int Immunol, 2002,14(3):287–297

    Article  PubMed  CAS  Google Scholar 

  15. Takahashi K, Oharaseki T, Naoe S. Neutrophilic involvement in the damage to coronary arteries in acute stage of Kawasaki disease. Pediatr INT: Official J Jpn Pediatr Society, 2005,47(3):305–310

    Google Scholar 

  16. Saji T. Clinical utility of ulinastatin, urinary protease inhibitor in acute Kawasaki disease. Nippon Rinsho, 2008,66(2):343–348

    PubMed  Google Scholar 

  17. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost, 2010,8(1): 148–156

    Article  PubMed  CAS  Google Scholar 

  18. Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 2004,103(6):2096–2104

    Article  PubMed  CAS  Google Scholar 

  19. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest, 2005,115(12):3378–3384

    Article  PubMed  CAS  Google Scholar 

  20. O’Malley T, Langhorne P, Elton RA, et al. Platelet size in stroke patients. Stroke, 1995,26(6):995–999

    Article  PubMed  Google Scholar 

  21. Bessman JD, Williams LJ, Gilmer PR Jr. Platelet size in health and hematologic disease. Am J Clin Pathol, 1982, 78(2):150–153

    PubMed  CAS  Google Scholar 

  22. Hirsh R, Landt Y, Portor S, et al. Cardial troponin I in pediatrics: normal values and potential use in the assessment of cardiac injury. J Padiatr, 1997,130(6):872

    Article  Google Scholar 

  23. Kim M. Elevation of cardiac troponin I in the acute stage of Kawasaki disease. Pediatr Cardiol, 1999,20(3):184–188

    Article  PubMed  CAS  Google Scholar 

  24. Lavallee M, Thorim E. Role of ET-1 in the regulation of coronary circulation. Can J Physiol Pharmacol, 2003,81(6): 570–577

    Article  PubMed  CAS  Google Scholar 

  25. Durongpisitkul K, Soongswang J, Laohaprasitiporn D, et al. Immunoglobulin failure and retreatment in Kawasaki disease. Pediatr Cardiol, 2003,24(2):145–148

    Article  PubMed  CAS  Google Scholar 

  26. Beiser AS, Takahashi M, Bake AL, et al. A predictive instrument for coronary artery aneurysms in Kawasaki disease. US Multicenter Kawasaki Disease Study Group. Am J Cardiol, 1998,81(9):1116–1120

    Article  PubMed  CAS  Google Scholar 

  27. Liu JP. Systematic review of not-randomized research (Chinese). J Evid Based Med, 2001,1(3):137

    Google Scholar 

  28. Jibiki T, Terai M, Kurosaki T, et al. Efficacy of intravenous immune globulin therapy combined with dexamethasone for the initial treatment of acute Kawasaki disease. Eur J Pediatr, 2004,163(4–5):229–233

    Article  PubMed  CAS  Google Scholar 

  29. Okada Y, Shinohara M, Kobayashi T, et al. Gunma Kawasaki Disease Study Group. Effect of corticosteroids in addition to intravenous gamma globulin therapy on serum cytokine levels in the acute phase of Kawasaki disease in children. J Pediatr, 2003,143(3):363–367

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jingjing Chen  (陈晶晶), Yali Liu  (刘亚黎) & Zubo Wu  (吴祖波)

  2. Department of Epidemiology and Health Statistics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Wenhua Liu  (刘文华)

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  1. Jingjing Chen  (陈晶晶)
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  2. Yali Liu  (刘亚黎)
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  3. Wenhua Liu  (刘文华)
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  4. Zubo Wu  (吴祖波)
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Correspondence to Yali Liu  (刘亚黎).

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Chen, J., Liu, Y., Liu, W. et al. A meta-analysis of the biomarkers associated with coronary artery lesions secondary to Kawasaki disease in Chinese children. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 31, 705–711 (2011). https://doi.org/10.1007/s11596-011-0587-9

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  • DOI: https://doi.org/10.1007/s11596-011-0587-9

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