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Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study

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Abstract

Previous evidences support that increased oxidative stress (OxS) may play an important role in metabolic syndrome (MetS) and both are closely linked to vascular dysfunction. This study determined whether there is a relationship between endothelial function and relative telomere length (RTL) in MetS subjects. In this cross-sectional study from the LIPGENE cohort, a total of 88 subjects (36 men and 52 women) were divided into four groups by quartiles of telomere length. We measured ischemic reactive hyperemia (IRH), total nitrite (NO) and protein carbonyl (PC) plasma levels, F2-isoprostanes urinary levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. IRH and NO plasma levels were higher in subjects with longer RTL (quartiles 3 and 4), while PC plasma levels, F2-isoprostanes urinary levels, and GPx and SOD plasma activities were lower in quartile 4 subjects (longest RTL). Additionally, MetS subjects with longer RTL had greater homeostatic model assessment-β level and lower triglycerides plasma levels. Our results suggest that endothelial dysfunction, associated with high levels of OxS, could be entailed in an increment of telomere attrition. Thus, further support of the molecular and cellular mechanisms involved in vascular dysfunction may contribute to the development of strategies to decelerate vascular aging or prevent cardiovascular disease.

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Acknowledgments

This research was supported partly by grants from the Ministerio de Ciencia e Innovacion (AGL2006-01979, AGL2009-12270 to JL-M), (‘CB06/03/0047-CIBER Fisiopatologia de la Obesidad y Nutricion’ is an ISCIII grant awarded to FP-J), Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia (P06-CTS-01425 and CVI-7450 to JL-M), and Consejeria de Salud, Junta de Andalucia (06/128, 07/43,

PI0193/2009 to JL-M, 06/129 to FP-J).

Author information

Authors and Affiliations

  1. Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, Avda. Menendez Pidal, s/n., 14004, Córdoba, Spain

    Lorena González-Guardia, Oriol Rangel-Zuñiga, Carmen Marin, Antonio Camargo, Pablo Pérez-Martínez, Javier Delgado-Lista, Francisco Gómez-Delgado, Antonio Garcia-Rios, Francisco Pérez-Jiménez & José López-Miranda

  2. CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain

    Lorena González-Guardia, Oriol Rangel-Zuñiga, Carmen Marin, Antonio Camargo, Pablo Pérez-Martínez, Francisco Gómez-Delgado, Antonio Garcia-Rios, Francisco José Tinahones, Francisco Pérez-Jiménez & José López-Miranda

  3. Division of Experimental Diabetes and Aging, Department of Geriatrics and Palliative Care, Mount Sinai School of Medicine, New York, USA

    Elena María Yubero-Serrano

  4. Biomedical Research Laboratory, Endocrinology Department, Hospital Virgen de la Victoria, Malaga, Spain

    Francisco José Tinahones

  5. Nutrigenomics Research Group, School of Public Health and Population Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

    Helen M. Roche

Authors
  1. Lorena González-Guardia
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  2. Elena María Yubero-Serrano
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  3. Oriol Rangel-Zuñiga
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  4. Carmen Marin
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  5. Antonio Camargo
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  6. Pablo Pérez-Martínez
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  7. Javier Delgado-Lista
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  8. Francisco Gómez-Delgado
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  9. Antonio Garcia-Rios
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  10. Francisco José Tinahones
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  11. Helen M. Roche
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  12. Francisco Pérez-Jiménez
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  13. José López-Miranda
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Corresponding author

Correspondence to José López-Miranda.

Additional information

Lorena González-Guardia and Elena María Yubero-Serrano contributed equally to this work.

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González-Guardia, L., Yubero-Serrano, E.M., Rangel-Zuñiga, O. et al. Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study. AGE 36, 9681 (2014). https://doi.org/10.1007/s11357-014-9681-9

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  • DOI: https://doi.org/10.1007/s11357-014-9681-9

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