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A comparative cellular and molecular biology of longevity database

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Abstract

Discovering key cellular and molecular traits that promote longevity is a major goal of aging and longevity research. One experimental strategy is to determine which traits have been selected during the evolution of longevity in naturally long-lived animal species. This comparative approach has been applied to lifespan research for nearly four decades, yielding hundreds of datasets describing aspects of cell and molecular biology hypothesized to relate to animal longevity. Here, we introduce a Comparative Cellular and Molecular Biology of Longevity Database, available at (http://genomics.brocku.ca/ccmbl/), as a compendium of comparative cell and molecular data presented in the context of longevity. This open access database will facilitate the meta-analysis of amalgamated datasets using standardized maximum lifespan (MLSP) data (from AnAge). The first edition contains over 800 data records describing experimental measurements of cellular stress resistance, reactive oxygen species metabolism, membrane composition, protein homeostasis, and genome homeostasis as they relate to vertebrate species MLSP. The purpose of this review is to introduce the database and briefly demonstrate its use in the meta-analysis of combined datasets.

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Authors and Affiliations

  1. Department of Biological Sciences, Brock University, St. Catharines, ON, Canada, L2S 3A1

    Jeffrey A. Stuart, Ping Liang, Xuemei Luo, Emily J. Gallagher, Casey A. Christoff & Ellen L. Robb

  2. Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK, AB24 2TZ

    Melissa M. Page

Authors
  1. Jeffrey A. Stuart
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  2. Ping Liang
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  3. Xuemei Luo
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  4. Melissa M. Page
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  5. Emily J. Gallagher
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  6. Casey A. Christoff
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  7. Ellen L. Robb
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Correspondence to Jeffrey A. Stuart.

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Stuart, J.A., Liang, P., Luo, X. et al. A comparative cellular and molecular biology of longevity database. AGE 35, 1937–1947 (2013). https://doi.org/10.1007/s11357-012-9458-y

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  • DOI: https://doi.org/10.1007/s11357-012-9458-y

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