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Effects of Ethanol Exposure During Early Pregnancy in Hyperactive, Inattentive and Impulsive Behaviors and MeCP2 Expression in Rodent Offspring

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Abstract

Prenatal exposure to alcohol has consistently been associated with adverse effects on neurodevelopment, which is collectively called fetal alcohol spectrum disorder (FASD). Increasing evidence suggest that prenatal exposure to alcohol increases the risk of developing attention deficit/hyperactivity disorder-like behavior in human. In this study, we investigated the behavioral effects of prenatal exposure to EtOH in offspring mice and rats focusing on hyperactivity and impulsivity. We also examined changes in dopamine transporter and MeCP2 expression, which may underlie as a key neurobiological and epigenetic determinant in FASD and hyperactive, inattentive and impulsive behaviors. Mouse or rat offspring born from dam exposed to alcohol during pregnancy (EtOH group) showed hyper locomotive activity, attention deficit and impulsivity. EtOH group also showed increased dopamine transporter and norepinephrine transporter level compared to control group in the prefrontal cortex and striatum. Prenatal exposure to EtOH also significantly decreased the expression of MeCP2 in both prefrontal cortex and striatum. These results suggest that prenatal exposure to EtOH induces hyperactive, inattentive and impulsive behaviors in rodent offspring that might be related to global epigenetic changes as well as aberration in catecholamine neurotransmitter transporter system.

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Acknowledgments

This research was supported by research grants (09162KFDA566, 11182KFDA556) from the Korea Food & Drug Administration in 2009 and 2011.

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Authors and Affiliations

  1. Department of Neuroscience, School of Medicine and Neuroscience Research Center, Institute SMART-IABS, Konkuk University, Seoul, 143-701, Korea

    Pitna Kim, Jin Hee Park, Chang Soon Choi, Inah Choi, So Hyun Joo, Min Kyoung Kim, Soo Young Kim, Ki Chan Kim, Seung Hwa Park, Kyoung Ja Kwon, Jongmin Lee, Seol-Heui Han, Ki Narm Ko & Chan Young Shin

  2. Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 1 Hoeki-dong, Dongdaemoon-Gu, Seoul, 130-701, Korea

    Jong Hoon Ryu

  3. College of Pharmacy, Uimyong Research Institute for Neuroscience, Samyook University, Nowon-goo, Seoul, 139-742, Korea

    Jae Hoon Cheong

  4. Korean Mother Risk Program, Department of Obstetrics and Gynecology, Cheil Hospital and Women’s Healthcare Center, Kwandong University College of Medicine, Seoul, Korea

    Jung Yeol Han

  5. Department of Pharmacology, School of Medicine, Konkuk University, 1 Hwayang-Dong, Gwangjin-Gu, Seoul, 143-701, Korea

    Chan Young Shin

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  1. Pitna Kim
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Correspondence to Chan Young Shin.

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Pitna Kim and Jin Hee Park are equally contributed to this work.

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Kim, P., Park, J.H., Choi, C.S. et al. Effects of Ethanol Exposure During Early Pregnancy in Hyperactive, Inattentive and Impulsive Behaviors and MeCP2 Expression in Rodent Offspring. Neurochem Res 38, 620–631 (2013). https://doi.org/10.1007/s11064-012-0960-5

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