Abstract
Myb genes are a family of transcription factors and have been implicated in the control of the proliferation and differentiation of normal and transformed cells. c-Myb is the best characterized member of the myb family. In the present study, we investigated age-dependent changes of c-myb immunoreactivity, its protein and mRNA level in the hippocampus proper (CA1–3 regions) at various age stages in gerbils. In the postnatal month 1 (PM 1) group, c-myb immunoreactivity was detected in non-pyramidal neurons of the strata oriens and radiatum as well as in pyramidal neurons of the stratum pyramidale. At PM 3, c-myb immunoreactivity and its protein level were similar to those at PM 1. Thereafter, c-myb immunoreactivity and its protein level were increased with time. In the PM 24 group, c-myb immunoreactivity, its protein and mRNA levels were highest. These results suggest that the significant increase of c-myb immunoreactivity, protein and mRNA levels in the aged hippocampus may be associated with neuronal aging.
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Acknowledgments
The authors would like to thank Mr Seok Han, Mr Seung Uk Lee and Ms Hyun Sook Kim for their technical help in this study. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A020007).
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Hwang, I.K., Moon, S.M., Yoo, KY. et al. c-Myb Immunoreactivity, Protein and mRNA Levels Significantly Increase in the Aged Hippocampus Proper in Gerbils. Neurochem Res 32, 1091–1097 (2007). https://doi.org/10.1007/s11064-006-9278-5
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DOI: https://doi.org/10.1007/s11064-006-9278-5