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Fatal Cases of Bloodstream Infection by Fusarium solani and Review of Published Literature

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Abstract

Fusarium species are ubiquitously present in environment and are well known as human pathogens with high mortality rate in immunocompromised patients. We report here two cases where immunocompromised patients developed fatal bloodstream infections by this organism. Isolates were further identified by ITS1 region sequencing which confirmed them as Fusarium solani. Antifungal susceptibility testing was done following CLSI M38-A2 guidelines to amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, caspofungin, and micafungin. Both patients had a fatal outcome and expired of septic shock. Therefore, identification up to species level is of utmost importance as that helps in directing the management of the patient thereby leading to a favourable outcome.

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Authors and Affiliations

  1. Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Yubhisha Dabas & Immaculata Xess

  2. Department of Medical Oncology, BRA-IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Sameer Bakhshi

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  1. Yubhisha Dabas
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  3. Immaculata Xess
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Correspondence to Immaculata Xess.

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Dabas, Y., Bakhshi, S. & Xess, I. Fatal Cases of Bloodstream Infection by Fusarium solani and Review of Published Literature. Mycopathologia 181, 291–296 (2016). https://doi.org/10.1007/s11046-015-9960-8

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  • DOI: https://doi.org/10.1007/s11046-015-9960-8

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