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Gastrointestinal Histoplasmosis in a Hepatitis C-Infected Individual

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Abstract

Gastrointestinal histoplasmosis is a rare manifestation of this fungal infection, typically identified in immunocompromised patients, such as those with HIV/AIDS. Here, we report a case of disseminated histoplasmosis with gastrointestinal involvement in a Hepatitis C-infected patient. The fungal agent was confirmed to be Histoplasma capsulatum by a DNA probe assay performed on a bone marrow sample. We propose that this fungal disease should be kept on the differential of patients infected with the Hepatitis C virus, as it has been reported to have numerous damaging effects on the adaptive immune system.

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References

  1. Baddley JW, et al. Geographic distribution of endemic fungal infections among older persons, United States. Emerg Infect Dis. 2011;17:1664–9.

    Article  PubMed  Google Scholar 

  2. Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev. 2007;20:115–32.

    Article  PubMed  CAS  Google Scholar 

  3. Cappell MS, Mandell W, Grimes MM, Neu HC. Gastrointestinal histoplasmosis. Dig Dis Sci. 1988;33:353–60.

    Article  PubMed  CAS  Google Scholar 

  4. Arango M, et al. Histoplasmosis: results of the Colombian National Survey, 1992–2008. Biomedica. 2012;31:344–56.

    Google Scholar 

  5. Kahi CJ, Wheat LJ, Allen SD, Sarosi GA. Gastrointestinal histoplasmosis. Am J Gastroenterol. 2005;100:220–31.

    Article  PubMed  Google Scholar 

  6. Klco JM, et al. Bone marrow biopsy in patients with hepatitis C virus infection: spectrum of findings and diagnostic utility. Am J Hematol. 2010;85:106–10.

    Article  PubMed  Google Scholar 

  7. Brenndorfer ED, Sallberg M. Hepatitis C virus-mediated modulation of cellular immunity. Arch Immunol Ther Exp (Warsz). 2012;60:315–29.

    Article  Google Scholar 

  8. Colaiacovo R, de Castro AC, Shiang C, Ganc RL, Ferrari AP. Disseminated histoplasmosis: a rare cause of multiple ulcers in the gastrointestinal tract. Endoscopy. 2011;43(2 UCTN):E216.

    Article  PubMed  Google Scholar 

  9. Shahani L. Disseminated histoplasma and CMV infection presenting as subacute intestinal obstruction in an immunocompromised patient. BMJ Case Rep 2012; bcr0820114732.

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Acknowledgments

V·B. received support from the Edward and Josephine Hudson Scholarship Fund.

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Authors and Affiliations

  1. Department of Pathology, Ben Taub General Hospital, Houston, TX, USA

    Paul M. Rodriguez-Waitkus, Elias George & Norbert Sule

  2. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA

    Paul M. Rodriguez-Waitkus, Elias George & Norbert Sule

  3. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA

    Vafa Bayat

Authors
  1. Paul M. Rodriguez-Waitkus
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  2. Vafa Bayat
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  3. Elias George
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  4. Norbert Sule
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Correspondence to Paul M. Rodriguez-Waitkus.

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Rodriguez-Waitkus, P.M., Bayat, V., George, E. et al. Gastrointestinal Histoplasmosis in a Hepatitis C-Infected Individual. Mycopathologia 176, 161–164 (2013). https://doi.org/10.1007/s11046-013-9669-5

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  • DOI: https://doi.org/10.1007/s11046-013-9669-5

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