Abstract
Paracoccidioidomycosis (PCM) is a severe systemic mycosis, endemic in Latin America and highly prevalent in Brazil, where it ranks eighth as a mortality cause among infectious and parasitic diseases in humans. The disease in animals has been little explored. It is observed that armadillos can harbor the fungus at high frequencies, although the active disease has not been well documented in this wild mammal. Dogs are susceptible to experimental infection, and the naturally acquired PCM-disease was reported only recently in a dog from Brazil. The present work reports the second case of naturally acquired PCM in a 6-year-old female dog that presented emaciation, lymphadenomegaly, and hepatosplenomegaly. Biochemical and pulmonary radiographic evaluation did not reveal any abnormalities. PCM was diagnosed by clinical findings, culturing, immunohistochemistry, and histopathology of popliteal lymph node. The fungus was recovered from popliteal lymph node, and the molecular analysis showed respective sequencing similarities of 99 and 100% for 803 nucleotides of the Gp43 gene and 592 nucleotides from the ITS-5.8S region of Paracoccidioides brasiliensis. Immunohistochemistry revealed severe lymphadenitis and presented numerous yeasts, which reacted against the gp43 antibody. Histopathology revealed a severe granulomatous lymphadenitis associated with numerous single or multiple budding yeasts. After diagnosis, the dog was successfully treated with itraconazol for 2 years. Veterinarians should be aware of the importance of considering PCM for differential diagnosis, especially in dogs from PCM-endemic areas, whose monophagocytic system involvement is evident.
References
Untereiner WA, Scott JA, Naveau FA, et al. The Ajellomycetaceae, a new family of vertebrate-associated Onygenales. Mycologia. 2004;96:812–21.
Wanke B, Londero AT. Epidemiology and paracoccidioidomycosis infection. In: Franco M, Lacaz CS, Restrepo A, Del Negro G, editors. Paracoccidioidomycosis. Boca Raton: CRS Press; 1994. p. 109–20.
Coutinho ZF, Silva D, Lazera M, et al. Paracoccidioidomycosis mortality in Brazil (1980–1995). Cad Saude Publica. 2002;18:1441–54.
Franco M, Montenegro M, Mendes RP. Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev Soc Bras Med Trop. 1987;20:129–32.
Shikanai-Yasuda MA, Telles Filho FQ, Mendes RP, et al. Consenso em Paracoccidioidomicose. Rev Soc Bras Med Trop. 2006;39:297–310.
Costa EO, Diniz LSM, Fava-Netto C, et al. Delayed hypersensitivity test with paracoccidioidin in captive Latin American wild mammals. J Med Vet Mycol. 1995;33:39–42.
Costa EO, Diniz LSM, Fava-Netto C. The prevalence of positive intradermal reactions to paracoccidioidin in domestic and wild animals in São Paulo. Brazil Vet Res Commun. 1995;19:127–30.
Costa EO, Fava-Netto C. Contribution to the epidemiology of paracoccidioidomycosis and histoplasmosis in the State of São Paulo, Brazil. Paracoccidioidin and histoplasmin intradermic tests in domestic animals. Sabouraudia. 1978;16:93–101.
Ono MA, Bracarense AP, Morais HS, Trapp SM, Belitardo DR, Camargo ZP. Canine paracoccidioidomycosis: a seroepidemiologic study. Med Mycol. 2001;39:277–82.
Bagagli E, Franco M, Bosco SMG, et al. High frequency of Paracoccidioides brasiliensis infection in armadillos (Dasypus novemcinctus): an ecology study. Med Mycol. 2003;41:217–23.
Ricci G, Mota FT, Wakamatsu A, Sakamatsu A, Serafim RC, Franco M. Canine paracoccidioidomycosis. Med Mycol. 2004;42:379–83.
Bosco SMG, Theodoro RC, Macoris SAG, et al. Morphological and molecular characterization of the first isolate of Paracoccidioides brasiliensis from dog (Canis familiaris) naturally infected. Rev Inst Med Trop São Paulo. 2005;47(suppl 14):62–3.
Eisele RC, Juliani RC, Belitardo DR, Itano EN, Estevão D, Bracarense APFRL, Camargo ZP, Ono MA. Immune response in dogs experimentally infected with Paracoccidioides brasiliensis. Med Mycol. 2004;42:549–53.
Franco M, Bagagli E, Scapolio S, Lacaz CS. A critical analysis of isolation of Paracoccidioides brasiliensi from soil. Med Mycol. 2000;38:185–91.
Centers for Disease Control and Prevention (CDC). Outbreak of histoplasmosis among travelers returning from El Salvador-Pennsylvania and Virginia. Morb Mortal Wkly Rep. 2008;57:1349–1353.
Taboada J. Micoses Sistêmicas. In: Ettinger SJ, Feldman EC, editors. Tratado de medicina interna veterinária: doenças do cão e do gato. Rio de Janeiro: Guanabara Koogan; 2004. p. 478–503.
Morais FV, Barros TF, Kukada MK, Cisalpino PS, Puccia R. Polymorphism in the gene coding for the immunodominant antigen gp43 from the pathogenic fungus Paracoccidioides brasiliensis. J Clin Microbiol. 2000;38(11):3960–6.
Matute DR, Quesada-Ocampo LM, Rauscher JT, McEwen JG. Evidence for positive selection in putative virulence factors within the Paracoccidioides brasiliensis species complex. PLoS Negl Trop Dis. 2008;172(9):e296.
Marques SA. Paracoccidioidomicose: atualização epidemiológica, clínica e terapêutica. An Bras Dermtol. 2003;78:135–50.
Valle ACF, Wanke B, Wanke N, et al. Tratamento da paracoccidioidomicose: estudo retrospectivo de 500 casos. II–Avaliação dos resultados terapêuticos com sulfanamídicos, anfotericina B, associação sulfometoxazol/trimetropim, cetoconazol e miconazol. An Bras Dermatol. 1993;68:65–70.
Ono MA, Kishima MO, Itano EN, Bracarense APFRL, Camargo ZP. Experimental paracoccidiomycosis in dogs. Med Mycol. 2003;41:265–8.
Fontana FF, Santos CTB, Esteves FM, Rocha A, Fernandes GF, Amaral CC, Domingues MA, Camargo ZP, Silva-Vergara, ML. Seroepidemiological survey of paracoccidioidomycosis infection among urban and rural dogs from Uberaba, Minas Gerais, Brazil. Mycopathologia. 2009; 169(3): 159–155 (Epub ahead of print).
Mós EN, Fava-Netto C. Contribuição ao estudo da paracoccidioidomicose I. Possível papel epidemiológico dos cães. Estudo sorológico e anátomo-patológico. Rev Inst Med Trop São Paulo. 1974;16:154–9.
Baumgardener DJ, Paretsky DP, Yopp AC. The epidemiology of blastomycosis in dogs: north central Wisconsin, USA. J Med Vet Mycol. 1995;33(3):171–6.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rodrigues de Farias, M., Anuska Zeni Condas, L., Garcia Ribeiro, M. et al. Paracoccidioidomycosis in a Dog: Case Report of Generalized Lymphadenomegaly. Mycopathologia 172, 147–152 (2011). https://doi.org/10.1007/s11046-011-9412-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11046-011-9412-z