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The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARγ) is associated with risk of coronary artery disease: a meta-analysis

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Abstract

The researches attempting to associate the PPARγ C161T polymorphism with coronary artery disease (CAD) yielded complicated and contradictory results. We aimed for more precise estimate of the relationship and conducted a comprehensive meta-analysis. Publications written in English or Chinese were screened in MEDLINE, Embase, CNKI, Wanfang and CBM. Data on 11 studies including 3,020 cases and 2,853 controls were extracted. A random-effects model was available to synthesize the inconsistent outcomes of the individual studies, while addressing between-study heterogeneity and publication bias. The PPARγ C161T polymorphism followed Hard-Weinberg Equilibrium for all studies (P > 0.05).Overall, there was no evidence for a significant association under all genetic models but with distinct heterogeneity (T vs. C: P = 0.29, OR = 0.91, 95 %CI 0.77–1.08, P heterogeneity = 0.004, I 2 = 61.2 %). However, in the subgroup analysis by ethnicity, the T allele carriers showed a prominent 26 % risk reduction of CAD among Chinese (dominant genetic model: P = 0.03, 95 %CI 0.57–0.97, P heterogeneity = 0.03, I 2 = 56.1 %). After dividing into population source, the significance of CAD risk reduction was strengthened in hospital-based studies (allele comparison: P = 0.04, OR = 0.82, 95 %CI 0.67–1.00, P heterogeneity = 0.04, I 2 = 52.5 %; dominant model: P = 0.01, OR = 0.73, 95 %CI 0.57–0.92, P heterogeneity = 0.05, I 2 = 50.8 %). There was no obvious publication bias verified in the method of funnel plot and Egger’s linear regression test (t = −0.11, P = 0.913). Taken together, our results revealed the PPARγ C161T polymorphism might play a moderate protective effect on developing CAD among Chinese, but not among Caucasians.

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Acknowledgments

This work was supported by the Shanghai excellent young teachers training fund of colleges and universities (jdy09097) and the science and technology fund of Shanghai Jiao Tong University School of Medicine (11XJ21001).

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The authors have declared that no competing interests exist.

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Authors and Affiliations

  1. Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Ruijin Second Road 197, Shanghai, 200025, China

    Zhijun Wu, Wei Jin, Yan Liu, Lin Lu & Guoping Lu

  2. Department of Pulmonary, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, Huaihai West Road 241, Shanghai, 200030, China

    Yuqing Lou

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  1. Zhijun Wu
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  2. Yuqing Lou
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  3. Wei Jin
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  4. Yan Liu
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Correspondence to Zhijun Wu.

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Zhijun Wu, Yuqing Lou contributed equally to this work.

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Wu, Z., Lou, Y., Jin, W. et al. The C161T polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPARγ) is associated with risk of coronary artery disease: a meta-analysis. Mol Biol Rep 40, 3101–3112 (2013). https://doi.org/10.1007/s11033-012-2384-3

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  • DOI: https://doi.org/10.1007/s11033-012-2384-3

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