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Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus

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Abstract

The vitamin D receptor (VDR) gene polymorphisms have been suggested to be involved in the development of diabetes mellitus, including type 1 diabetes (T1DM) and type 2 diabetes (T2DM). However, the results have been inconsistent. In this study, we performed a meta-analysis to investigate the associations. Literature was retrieved from PubMed, ISI Web of Science and Chinese databases. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated using a random or fixed effect model. 79 studies (FokI: 22 studies; BsmI: 25 studies; ApaI: 17 studies; TaqI: 15 studies) on T1DM and 44 studies (FokI: 10 studies; BsmI: 10 studies; ApaI: 14 studies; TaqI: 10 studies) on T2DM were included. The results indicated that BsmI polymorphism was associated with an increased risk of T1DM (B vs. b: OR 1.31, 95 % CI 1.10–1.55, P = 0.002), especially in East Asians (B vs. b: OR 2.57, 95 % CI: 1.55–4.24, P < 0.001); FokI polymorphism was associated with an increased risk of T2DM (f vs. F: OR 1.30, 95 % CI: 1.17–1.45, P < 0.001), especially in East Asians (f vs. F: OR 1.36, 95 % CI: 1.21–1.54, P < 0.001). However, no significant association was observed between ApaI or TaqI polymorphism and diabetes risk with the exception of significant association between ApaI polymorphism and T1DM risk in East Asians. Thus, the authors found BsmI polymorphism in the VDR gene may increase the risk of T1DM in East Asians and the FokI polymorphism may increase the risk of T2DM in East Asians.

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  1. Department of Maternal and Child Health Care, School of Public Health, Shandong University, No 44 Wenhuaxi Road, Jinan, 250012, China

    Qijuan Wang, Bo Xi, Man Liu & Maosun Fu

  2. Tulane University Health Sciences Center, School of Public Health and Tropical Medicine, New Orleans, LA, USA

    Kathleen Heather Reilly

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Supplementary material 1 (DOCX 41 kb)

11033_2012_1805_MOESM2_ESM.tif

Supplementary Fig. 1. Meta-analysis of the association between FokI polymorphism in the VDR gene and type 1 diabetes (f vs. F) (TIFF 1579 kb)

11033_2012_1805_MOESM3_ESM.tif

Supplementary Fig. 2. Meta-analysis of the association between ApaI polymorphism in the VDR gene and type 1 diabetes (a vs. A) (TIFF 1703 kb)

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Supplementary Fig. 3. Meta-analysis of the association between TaqI polymorphism in the VDR gene and type 1 diabetes (t vs. T) (TIFF 1794 kb)

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Supplementary Fig. 4. Meta-analysis of the association between BsmI polymorphism in the VDR gene and type 2 diabetes (B vs. b) (TIFF 1672 kb)

11033_2012_1805_MOESM6_ESM.tif

Supplementary Fig. 5. Meta-analysis of the association between ApaI polymorphism in the VDR gene and type 2 diabetes (a vs. A) (TIFF 1767 kb)

11033_2012_1805_MOESM7_ESM.tif

Supplementary Fig. 6. Meta-analysis of the association between TaqI polymorphism in the VDR gene and type 2 diabetes (t vs. T) (TIFF 1839 kb)

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Wang, Q., Xi, B., Reilly, K.H. et al. Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus. Mol Biol Rep 39, 9405–9414 (2012). https://doi.org/10.1007/s11033-012-1805-7

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