Abstract
The association between single-nucleotide polymorphisms (SNPs) of the CYP1B1 gene and lung cancer risk is still ambiguous. In this meta analysis, we assessed 10 case–control studies included 7,067 cases and 9,374 controls of the association between CYP1B1 SNPs of Leu432Val (rs1056836, 432C>G), Asn453Ser (rs1800440, 453A>G), Ala119Ser (rs1056827, 119G>T), Arg48Gly (rs10012, 48C>G) and the risk of lung cancer. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between the polymorphism and lung cancer risk under codominant model, dominant model and additive model respectively. Although there were limitations, this meta analysis indicated that individuals with 432GG genotype had a 39.7% higher risk of having lung cancer than those with the 432CC genotype, and individuals with the 432G allele had a 26.3% increased risk as well. An increased risk of lung cancer of 2.13 fold was observed in individuals with 119TT genotype. For Arg48Gly, individuals with 48GG genotype had a significantly increased risk of lung cancer compared with individuals with 48CC (OR 3.859; 95% CI 2.536–5.87). Elevated risk of lung cancer were observed in dominant model (OR 2.115; 95% CI 1.653–2.705) as well. The risk of lung cancer was elevated as the frequency of G allele increased in additive model (P = 0.000). For individuals with the polymorphism at codon 453, no evidence of such association was observed. Furthermore, a possible association between the CYP1B1 polymorphism at codon 432 and the lung cancer could be detected in individuals of Caucasian origin, while a negative association was suggested in Asians and African-Americans. An increased lung cancer risk was also found in women with polymorphism at codon 453. These results are supportive for the hypothesis that the CYP1B1 432GG, 119TT and 48GG genotypes are low-penetrance risk factors for developing lung cancer, and further studies are needed to validate these associations.
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References
Parkin DM, Bary F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108
Clemens MR (1991) Free radicals in chemical carcinogenesis. Klin Wochenschr 69:1123–1134
Sulhattin A, Sule K, Malik EY, Ozturk O, Ibrahim A (2011) The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk. Mol Biol Rep 38:991–996
Doll R, Peto R, Wheatley K, Grey R, Sutherland I (1994) Mortality in relation to smoking: 40 years’ observations on male British doctors. Br Med J 309:901–911
Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66:1191–1208
Hecht SS (1999) Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 91:1194–1210
Strange RC, Fryer AA (1999) The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ 148:231–249
Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, Inoue K (1999) Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis 20:1607–1613
Spivack SD, Hurteau GJ, Reilly AA, Aldous KM, Ding X, Kaminsky LS (2001) CYP1B1 expression in human lung. Drug Metab Dispos 29:916–922
Wu MF, Wu WJ, Chang GC, Chen CY, Hu SW, Tsai WT, Lee H, Lin P (2004) Increased expression of cytochrome P4501B1 in peripheral leukocytes from lung cancer patients. Toxicol Lett 150:211–219
Schoket B, Papp G, Levay K, Mrackova G, Kadlubar FF, Vincze I (2001) Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure. Mutat Res 482:57–69
Wenzlaff AS, Cote ML, Bock CH, Land SJ, Santer SK, Schwartz DR, Schwartz AG (2005) CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study. Carcinogenesis 26:2207–2212
Rotunno M, Yu K, Lubin JH, Consonni D, Pesatori AC, Goldstein AM, Goldin LR, Wacholder S, Welch R (2009) Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. PLoS ONE 4:e5652
Cote ML, Yoo W, Wenzlaff AS, Prysak GM, Santer SK, Claeys GB, Van Dyke AL, Land SJ, Schwartz AG (2009) Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis 30:626–635
Shah PP, Singh AP, Singh M, Mathur N, Mishra BN, Pant MC, Parmar D (2008) Association of functionally important polymorphisms in cytochrome P4501B1 with lung cancer. Mutat Res 643:4–10
Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland LB, Canzian F, Haugen A (2008) A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis 29:1164–1169
Yoon KA, Kim JH, Gil HJ, Hwang H, Hwangbo B, Lee JS (2008) CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women. Lung Cancer 60:40–46
Cote ML, Wenzlaff AS, Bock CH, Land SJ, Santer SK, Schwartz DR, Schwartz AG (2007) Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study. Lung Cancer 55:255–262
Sørensen M, Autrup H, Tjønneland A, Overvad K, Raaschou-Nielsen O (2005) Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer. Cancer Lett 221:185–190
Watanabe J, Shimada T, Gillam EM, Ikuta T, Suemasu K, Higashi Y, Gotoh O, Kawajiri K (2000) Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics 10:25–33
Timofeeva MN, Kropp S, Sauter W, Beckmann L, Rosenberger A, Illig T, Jager B, Mittelstrass K, Dienemann H, Bartsch H, Bickeboller H, Chang-Claude JC, Risch A, Wichmann HE, LUCY-Consortium (2009) CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences. Carcinogenesis 30:1161–1169
Liang G, Pu Y, Yin L (2005) Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population. Cancer Lett 233:265–274
Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K (2001) Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Drug Metab Dispos 29:1176–1182
Shimada T, Fujii-Kuriyama Y (2004) Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci 95:1–6
Stoilov I, Akarsu AN, Sarfarazi M (1997) Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21. Hum Mol Genet 6:641–647
Gotoh O (1992) Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J Biol Chem 267:83–90
Jaworowska E, Masojc B, Tarnowska C, Brzosko M, Flicinski J, Serrano-Fernandez P, Matyjasik J, Amernik K, Scott RJ, Lubinski J (2006) Association between early-onset breast and laryngeal cancers. Breast Cancer Res Treat 97:215–219
Ko Y, Abel J, Harth V, Brode P, Antony C, Donat S, Fischer HP, Ortiz-Pallardo ME, Thier R, Sachinidis A, Vetter H, Bolt HM, Herberhold C, Bruning T (2001) Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue. Cancer Res 61:4398–4404
Sasaki M, Tanaka Y, Okino ST, Nomoto M, Yonezawa S, Nakagawa M, Fujimoto S, Sakuragi N, Dahiya R (2004) Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer. Clin Cancer Res 10:2015–2019
Sasaki M, Tanaka Y, Kaneuchi M, Sakuragi N, Dahiya R (2003) CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions. Cancer Res 63:3913–3918
Tang YM, Green BL, Chen GF, Thompson PA, Lang NP, Shinde A, Lin DX, Tan W, Lyn-Cook BD, Hammons GJ, Kadlubar FF (2000) Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls. Pharmacogenetics 10:761–766
Rylander-Rudqvist T, Wedren S, Granath F, Humphreys K, Ahiberg S, Weiderpass E, Oscarson M, Ingelman-Sundberg M, Persson I (2003) Cytochrome P4501B1 gene polymorphisms and postmenopausal breast cancer risk. Carcinogenesis 24:1533–1539
Bailey LR, Roodi N, Dupont WD, Parl FF (1998) Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer. Cancer Res 58:5038–5041
Li DN, Seidel A, Paritchard MP, Wolf CR, Friedberg T (2000) Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol. Pharmacogenetics 10:343–353
Hanna IH, Dawling S, Roodi N, Guengerich FP, Parl FF (2000) Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Cancer Res 60:3440–3444
Miyoshi Y, Noguchi S (2003) Polymorphisms of estrogen synthesizing and metabolizing genes and breast cancer risk in Japanese women. Biomed Pharmacother 57:471–481
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Xu, W., Zhou, Y., Hang, X. et al. Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis. Mol Biol Rep 39, 2821–2829 (2012). https://doi.org/10.1007/s11033-011-1041-6
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DOI: https://doi.org/10.1007/s11033-011-1041-6