Abstract
Incorporation of a radioisotope of platinum prepared with sufficiently high specific activity into the cisplatin molecule may significantly enhance the antitumor effect and decrease the therapeutically effective dosage of cisplatin chemotherapy. The objectives of our research were to develop a method of preparation of 195mPt with high specific activity and then implement the synthesis of 195mPt-cisplatin for in vitro and animal studies of its antitumor effect in comparison with non-radioactive cisplatin. Investigation of cisplatin and 195mPt-cisplatin on Ehrlich solid carcinoma demonstrated tumor growth inhibition of 35 and 65 %, respectively, indicating 195mPt-cisplatin is more effective than non-radioactive cisplatin in antitumor activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dikij MP (2007) Methods of isotope production in linear electron accelerators for application in radiotherapy with the use of Auger-electrons. Ukr Radiol Z VXV:242
Sykes TR, Stephans-Newsham LG, Noujaim AA (1986) Reactor pro-duction and detection of radiolabeled cisplatin. Appl Radiat Isot 37:231–236
Soares MA, Mattos JL, Pujatti PB et al (2012) Evaluation of the synergetic radio-chemotherapy effects on the radio labeled cisplatin for the treatment of glioma. J Radioanal Nucl Chem 292:61
Neves M, Kling A, Lambrecht RM (2002) Radionuclide production for therapeutic radiopharmaceuticals. Appl Radiat Isot 57:657–664
FF Knapp Jr, Mirzadeh S, Beets AL, Du M (2005) Production of therapeutic radioisotopes in the ORNL high flux isotope reactor (HFIR) for applications in nuclear medicine, oncology and interventional cardiology. J Radioanal Nucl Chem 263:503
Nayak D, Lahiri S (1999) Application of radioisotopes in the field of nuclear medicine—I. Lanthanide series elements. J Radioanal Nucl Chem 242:423–432
Feinendegen IE (1975) Biological damage from the Auger effect: possible benefits. Radiat Environ Biophys 12:85–99
Adelstein SJ, Kassis AI (1987) Radiobiologic implications of the microscopic distribution of energy from radionuclides. Nucl Med Biol 14:165–169
Kassis AI, Adelstein SJ, Haycock CK et al (1982) Lethality of auger electrons from the decay of Br-77 in the DNA of mammalian cells. Radiat Res 90:362–373
Dadachova E, Howell RW, Bryan RA et al (2004) Cryptococcus neoformans and Histoplasma capsulatum to γ-radiation versus radioimmunotherapy with α- and β-emitting radioisotopes. Rad Suscep Hum Path 45:313
Howell RW, Sastry SR (1986) Cis-platinum-193 m: its microdosimetry and potential for chemo-Auger combination therapy of cancer. In: Proceedings of fourth international radiopharmaceutical dosimetry symposium, pp 493–513
Areberg J, Wennerberg J, Johnsson A et al (2001) Antitumor effect of radioactive cisplatin (191Pt) on nude mice. Int J Radiat Oncol Biol Phys 49:827–832
Chernyaev I (1964) Synthesis of complex compounds of metals from the platinum group. Nauka, Moscow, p 434
Toub M (1975) Mechanisms of inorganic reactions. Mir, Moscow, p 533
Dykiy MP, Dovbnya AN, Lyashko YuV et al (2007) Photonuclear production of 193m,195mPt and synthesis of radioactive cisplatin. J Label Compd Radiopharm 50:480
Acknowledgments
We are grateful for the financial support of the Science and Technology Center of Ukraine.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bodnar, E.N., Dikiy, M.P. & Medvedeva, .P. Photonuclear production and antitumor effect of radioactive cisplatin (195mPt). J Radioanal Nucl Chem 305, 133–138 (2015). https://doi.org/10.1007/s10967-015-4053-1
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10967-015-4053-1