The Ca2+ transport ATPase of intracellular membranes (SERCA) can be inhibited by a series of chemical compounds such as Thapsigargin (TG), 2,5-di(tert-butyl)hydroquinone (DBHQ) and 1,3-dibromo-2,4,6-tris (methyl-isothio-uronium) benzene (Br2-TITU). These compounds have specific binding sites in the ATPase protein, and different mechanisms of inhibition. On the other hand, SERCA gene silencing offers a convenient and specific method for suppression of SERCA activity in cells. The physiological and pharmacological implications of SERCA inhibition are discussed.
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Inesi, G., Hua, S., Xu, C. et al. Studies of Ca2+ ATPase (SERCA) Inhibition. J Bioenerg Biomembr 37, 365–368 (2005). https://doi.org/10.1007/s10863-005-9472-1
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DOI: https://doi.org/10.1007/s10863-005-9472-1