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Nano-scaled hydroxyapatite/polymer composite III. Coating of sintered hydroxyapatite particles on poly(4-methacryloyloxyethyl trimellitate anhydride)-grafted silk fibroin fibers

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Abstract

A novel composite coupling between nano-scaled hydroxyapatite (HAp) particles and poly[4-methacryloyloxyethyl trimellitate anhydride (4-META)]-grafted silk fibroin (SF) through ionic interaction was synthesized. The weight gain of poly(4-META) by graft-polymerization increased with increasing the reaction time, eventually reaching a plateau value of about 20 wt%. The HAp nano-particles were adsorbed equally and dispersively on the treated SF fiber surface. The HAp content in the composite was 4.554 wt% ± 0.098 (n = 4), confirmed by thermogravimetry (TG). This synthetic system requires no heat to connect HAp to SF and is useful when applying to non-heat-resistant polymers. The L-929 cell-adhesion test shows that the HAp/SF composite improves bioactivity compared to the original SF.

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Authors and Affiliations

  1. Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan

    Arata Korematsu, Tsutomu Furuzono, Shoji Yasuda & Akio Kishida

  2. PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

    Tsutomu Furuzono

  3. Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan

    Junzo Tanaka

Authors
  1. Arata Korematsu
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  2. Tsutomu Furuzono
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  3. Shoji Yasuda
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  4. Junzo Tanaka
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  5. Akio Kishida
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Correspondence to Tsutomu Furuzono.

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Korematsu, A., Furuzono, T., Yasuda, S. et al. Nano-scaled hydroxyapatite/polymer composite III. Coating of sintered hydroxyapatite particles on poly(4-methacryloyloxyethyl trimellitate anhydride)-grafted silk fibroin fibers. J Mater Sci: Mater Med 16, 67–71 (2005). https://doi.org/10.1007/s10856-005-6448-y

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  • DOI: https://doi.org/10.1007/s10856-005-6448-y

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