Abstract
Scurvy was diagnosed in seven children at Boston Children’s Hospital. All of the children had a developmental disorder and autism was the most common. They had a long-standing history of food selectivity with diets devoid of fruits and vegetables, and none of the children were supplemented with a multivitamin. They presented with limp, and an elaborate panel of tests and procedures were undertaken before the diagnosis of scurvy was made. Treatment with vitamin C led to rapid recovery of symptoms. This report emphasizes the importance of considering nutritional causes of musculoskeletal symptoms in children with autism and restrictive diets.
References
Agarwal, A., Shaharyar, A., Kumar, A., Bhat, M. S., & Mishra, M. (2015). Scurvy in pediatric age group—A disease often forgotten? Journal of Clinical Orthopaedics and Trauma, 6(2), 101–107.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
Brennan, C. M., Atkins, K. A., Druzgal, C. H., & Gaskin, C. M. (2012). Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation. Skeletal Radiology, 41(3), 357–360.
Cermak, S. A., Curtin, C., & Bandini, L. G. (2010). Food selectivity and sensory sensitivity in children with autism spectrum disorders. Journal of the American Dietetic Association, 110(2), 238–246.
Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention (CDC). (2014). Prevalence of autism spectrum disorder among children aged 8 years—Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(2), 1–21.
Duggan, C. P., Westra, S. J., & Rosenberg, A. E. (2007). Case records of the Massachusetts General Hospital. Case 23-2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy. New England Journal of Medicine, 357(4), 392–400.
Duvall, M. G., Pikman, Y., Kantor, D. B., et al. (2013). Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child. Pediatrics, 132(6), e1699–e1703.
Fain, O. (2005). Musculoskeletal manifestations of scurvy. Joint Bone Spine, 72(2), 124–128.
Gongidi, P., Johnson, C., & Dinan, D. (2013). Scurvy in an autistic child: MRI findings. Pediatric Radiology, 43(10), 1396–1399.
Gulko, E., Collins, L. K., Murphy, R. C., Thornhill, B. A., & Taragin, B. H. (2015). MRI findings in pediatric patients with scurvy. Skeletal Radiology, 44(2), 291–297.
Hodges, R. E., Baker, E. M., Hood, J., Sauberlich, H. E., & March, S. C. (1969). Experimental scurvy in man. American Journal of Clinical Nutrition, 22(5), 535–548.
Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. (2000). Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academies Press (US).
Kitcharoensakkul, M., Schulz, C. G., Kassel, R., et al. (2014). Scurvy revealed by difficulty walking: Three cases in young children. Journal of Clinical Rheumatology, 20(4), 224–228.
Levine, M. (1986). New concepts in the biology and biochemistry of ascorbic acid. New England Journal of Medicine, 314(14), 842–902.
Noble, J. M., Mandel, A., & Patterson, M. C. (2007). Scurvy and rickets masked by chronic neurologic illness: Revisiting “psychologic malnutrition”. Pediatrics, 119(3), e783–e790.
Olson, J. A., & Hodges, R. E. (1987). Recommended dietary intakes (RDI) of vitamin C in humans. American Journal of Clinical Nutrition, 45(4), 693–703.
Polat, A. V., Bekci, T., Say, F., Bolukbas, E., & Selcuk, M. B. (2015). Osteoskeletal manifestations of scurvy: MRI and ultrasound findings. Skeletal Radiology, 44(8), 1161–1164.
Ratanachu-Ek, S., Sukswai, P., Jeerathanyasakun, Y., & Wongtapradit, L. (2003). Scurvy in pediatric patients: A review of 28 cases. Journal of the Medical Association of Thailand, 86(Suppl 3), S734–S740.
Schleicher, R. L., Carroll, M. D., Ford, E. S., & Lacher, D. A. (2009). Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). American Journal of Clinical Nutrition, 90(5), 1252–1263.
Sharp, W. G., Berry, R. C., McCracken, C., et al. (2013). Feeding problems and nutrient intake in children with autism spectrum disorders: A meta-analysis and comprehensive review of the literature. Journal of Autism and Developmental Disorders, 43(9), 2159–2173.
Vanderslice, J. T., & Higgs, D. J. (1991). Vitamin C content of foods: Sample variability. American Journal of Clinical Nutrition, 54(6), 1323S–1327S.
Weinstein, M., Babyn, P., & Zlotkin, S. (2001). An orange a day keeps the doctor away: Scurvy in the year 2000. Pediatrics, 108(3), E55.
Acknowledgments
We acknowledge the patients, their families, and the teams of dedicated providers at BCH for working together toward a diagnosis of scurvy, with special thanks to Drs. Susan Connolly and Jeannette M. Perez-Rossello in the Department of Radiology.
Author Contributions
N.S.M. conceived of the study, participated in its design, acquisition and interpretation of data, and participated in drafting the manuscript; C.T. participated in the design, acquisition of data, and participated in drafting the manuscript; S.W. made substantial contributions to analysis and interpretation of data, was involved in critically revising the manuscript, and contributed to important sections pertaining to nutrition in the manuscript. All authors read and approved the final manuscript.
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Ma, N.S., Thompson, C. & Weston, S. Brief Report: Scurvy as a Manifestation of Food Selectivity in Children with Autism. J Autism Dev Disord 46, 1464–1470 (2016). https://doi.org/10.1007/s10803-015-2660-x
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DOI: https://doi.org/10.1007/s10803-015-2660-x