Skip to main content
Log in

Growth of Head Circumference in Autistic Infants During the First Year of Life

  • Original Paper
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

This study analyzed the increase in head circumference (HC) of 85 autistic infants (64 boys and 21 girls) during their first year of life. The data were collected from their “mother-and-baby” notebooks. This notebook is a medical record of the baby’s growth and development delivered to the parents of all babies born in Japan. This is a retrospective study which gathered the data from the notebooks after the diagnosis of autism. However, none of the babies were known to have autism at the time the records were made. The head circumference at birth of these autistic children was similar to that of the average found in a Japanese Government Study of 14,115 children. However, it showed a marked increase at 1 month after birth. The discrepancy reached a peak at 6 months, while the difference became smaller at 12 months. Body length (BL) and body weight (BW) began to increase at 3 months, although at a rate smaller than the head circumference increase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Bailey, A., Luthert, P., Bolton, P., LeCouteur, A., Rutter, M., & Harding, B. (1993). Autism and megalencephaly. Lancet, 341, 1225–1226.

    Article  PubMed  CAS  Google Scholar 

  • Bailey, A., LeCouteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.

    Article  PubMed  CAS  Google Scholar 

  • Bailey, A., Luthert, P., Dean, A., Harding, B., Janota, I., Montgomery, M., Rutter, M., & Lantos, P. (1998). A clinicalpathological study of autism. Brain, 121, 889–905.

    Article  PubMed  Google Scholar 

  • Bartholimeusz, H., Courchesne, E., & Karns, C. M. (2002). Relationship between head circumference and brain volume in healthy normal toddlers, children, and adults. Neuropediatrics, 33, 239–241.

    Article  Google Scholar 

  • Bauman, M. (1996). Neuroanatomic observations of the brain in pervasive development disorders. Journal of Autism and Developmental Disorders, 26, 199–203.

    Article  PubMed  CAS  Google Scholar 

  • Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M. (1994). A case–control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.

    Article  PubMed  CAS  Google Scholar 

  • Carper, R. A., Mses, P., Tigue, Z. D., & Courchesne, E. (2002). Cerebral lobes in autism; early hyperplasia and abnormal age effects. Neuroimage, 16, 1038–1051.

    Article  PubMed  Google Scholar 

  • Courchense, E. 2004. Brain development in autism: Early overgrowth followed by premature arrest of growth. Mental Retardation and Developmental Disabilities Research Reviews, 10, 106–111.

    Article  Google Scholar 

  • Courchense, E., & Pierce, K. (2005a). Why the frontal cortex in autism might be talking only to itself: Local over-connectivity but long-distance disconnection. Current Opinion in Neurobiology, 15, 225–230.

    Article  CAS  Google Scholar 

  • Courchense, E., & Pierce, K. (2005b). Brain overgrowth in autism during a critical time in development: Implications for frontal pyramidal neuron and interneuron development and connectivity. International Journal of Developmental Neuroscience, 23, 153–170.

    Article  Google Scholar 

  • Courchense, E., Carper, R., & Akshoomoff, N. (2003). Evidence of brain overgrowth in the first year of life in autism. Journal of the American Medical Association, 290, 337–344.

    Article  Google Scholar 

  • Courchene, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., Lincoln, A. J., Pizzo, S., Schrebman, L, Haas, R. H., Akshoomoff, N. A., & Courchesne, R. Y. (2001). Unusual brain growth patterns in early life in patients with autistic disorder. Neurology, 57, 245–254.

    Google Scholar 

  • Davidivitch, M., Patterson, B., & Gartside, P. (1996). Head circumference measurements in children with autism. Journal of Child Neurology, 11, 389–393.

    Article  Google Scholar 

  • Dawson, G., Munson, J., Webb, S. J., Nalty, T., Abbott, R., & Toth, K. (2007). Rate of head growth decelerates and symptoms worsen in the second year of life in autism. Biological Psychiatry, 61, 458–464.

    Article  PubMed  Google Scholar 

  • Dementieva, Y. A., Vance, D. D., Donnelly, S. L., Elston, L. A., Wolpert, C. M., Ravan, S. A., DeLong, G. R., Abramson, R. K., Wright, H., & Cuccaro, M. L. (2005). Accelerated head growth in early development of individuals with autism. Pediatric Neurology, 32, 102–108.

    Article  PubMed  Google Scholar 

  • Deutsh, C. K., & Joseph, R. M. (2003). Brief report; cognitive correlates of enlarged head circumference in children with autism. Journal of Autism and Developmental Disorders, 33, 209–215.

    Article  Google Scholar 

  • Dissanayake, C., Quang, M. B, Huggins, R., & Danuta, Z. L. (2006). Growth in stature and head circumference in high functioning autism and Asperger disorder during the first 3 years of life. Development and Psychopathology, 18, 381–393.

    Article  PubMed  Google Scholar 

  • Fidler, D. J., Bailey, J., & Smalley, S. (2000). Macrocephaly in autism and other pervasive developmental disorders. Developmental Medicine and Child Neurology, 42, 737–740.

    Article  PubMed  CAS  Google Scholar 

  • Fombonne, E., Rogé, B., Claverie, J., Courty, S., & Frémolle, J. (1999). Microcephaly and macrocephaly in autism. Journal of Autism and Developmental Disorders, 29, 113–119.

    Article  PubMed  CAS  Google Scholar 

  • Gillberg, C., & de Souza, L. (2002). Head circumference in autism, Asperger syndrome, and attention deficit/hyperactivity disorder (AD/HD): A comparative study. Developmental Medicine and Child Neurology, 44, 296–300.

    Article  PubMed  Google Scholar 

  • Hardan, A. Y., Minshew, N. J., Mallikarjuhn, M., & Keshavan, M. S. (2001). Brain volume in autism. Journal of Child Neurology, 16, 421–424.

    Article  PubMed  CAS  Google Scholar 

  • Hazlett, H. C., Poe, M., Gerig, G., Smith, R. G., Provenzale, J., Ross, A., Gilmore, J., & Piven, J. (2005). Magnetic resonance imaging and head circumference study of brain size in autism. Archives of General Psychiatry, 62, 1366–1376.

    Article  PubMed  Google Scholar 

  • Kemper, T. L., & Bauman, M. L. (1993). The contribution of neuropathologic studies to the understanding of autism. Neurologic Clinic, 11, 157–187.

    Google Scholar 

  • Kemper, T. L., & Bauman, M. L. (1998). Neuropathology of infantile autism. Journal of Neuropathology and Experimental Neurology, 57, 645–652.

    PubMed  CAS  Google Scholar 

  • Lainhart, J. E., Piven, J., Wzorek, M., Linda, R., Santangelo, S., Coon, H., & Folstein, S. E. (1997). Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 282–290.

    Article  PubMed  CAS  Google Scholar 

  • Lainhart, J. E., Bigler, E. D., Bocian, M., Coon, H., Dinh, E., Dawson, G., Deutsch, C. K., Dunn, M., Estes, A., Tager-Flusberg, H., Folstein, S., Hepburn, S., Hyman, S., McMahon, W., Minshew, N., Munson, J., Osann, K., Ozonoff, S., Patricia, R., Rogers, S., Sigman, M., Spence, M. A., Stodgell, C. J., & Volkmar, F. (2006). Head circumference and height in autism: A study by the collaborative program of excellence in autism. American Journal of Medical Genetics Part A, 140A, 2257–2274.

    Article  Google Scholar 

  • Miles, J. H., Hadden, L. L., Takahashi, T. N., & Hillman, R. E. (2000). Head circumference is an independent clinical finding associated with autism. American Journal of Medical Genetics, 95, 339–350.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, K. B., Grether, J. K., Croen, L. A., Dambrosia, J. M., Dickens, B. F., Jelliffe, L. L., Hansen, R. L., Phillips, T. M. (2001). Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Annuals of Neurology, 49, 597–606.

    Article  CAS  Google Scholar 

  • Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996). Regional brain enlargement in autism: A magnetic resonance imaging study. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 530–536.

    Article  PubMed  CAS  Google Scholar 

  • Piven, J., Arndt, S., Bailey, J., Havercamp, S., Andreasen, N. C., & Palmer, P. (1995). An MRI study of brain size in autism. American Journal of Psychiatry, 152, 1145–1149.

    PubMed  CAS  Google Scholar 

  • Rice, D., & Barone, S. Jr. (2000). Clinical periods of vulnerability for the developing nervous system; evidence from humans and animal models. Environmental Health Perspectives, 108, 511–533.

    Article  PubMed  Google Scholar 

  • Stevenson, R. E., Schroer, R. J., Skinner, C., Fonder, D., & Simensen, R. J. (1997). Autism and macrocephaly. Lancet, 349, 1744–1745.

    Article  PubMed  CAS  Google Scholar 

  • Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echeland, D., & Artru, A. A. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59, 184–192.

    PubMed  CAS  Google Scholar 

  • Torrey, T. F., Dhavale, D., Lawlor, J. P., & Yolken, R. H. (2004). Brief report; autism and head circumference in the first year of life. Biological Psychiatry, 56, 892–894.

    Article  PubMed  Google Scholar 

  • Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67–81.

    Article  PubMed  CAS  Google Scholar 

  • Woodhouse, W., Bailey, A., Rutter, M., Bolton, P., Baird, G., & le Couteur, A. (1996). Head circumference in autism and other pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 37, 665–671.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aya Fukumoto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fukumoto, A., Hashimoto, T., Ito, H. et al. Growth of Head Circumference in Autistic Infants During the First Year of Life. J Autism Dev Disord 38, 411–418 (2008). https://doi.org/10.1007/s10803-007-0405-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-007-0405-1

Keywords

Navigation