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Fluoxetine Monotherapy in Attention-Deficit/Hyperactivity Disorder and Comorbid Non-Bipolar Mood Disorders in Children and Adolescents

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Abstract

Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing comorbid non-bipolar mood disorders. Fluoxetine monotherapy is an established treatment for pediatric mood disorders; however its efficacy in ADHD and comorbid mood disorder is unknown. Therefore, we evaluated 30 children who met DSM-IV criteria for ADHD and comorbid non-bipolar mood disorders in a prospective, 6–12-week open-label, study of fluoxetine monotherapy. Fluoxetine was associated with significant decreases in the severity of depressive symptoms, and also, associated with significant decreases on subscales of inattention/overactivity and aggression/defiant symptoms—47% of participants were much or very much improved without observed adverse effects.

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Acnowledgments

The authors are thankful to Eli Lilly for their support of this research through Grant ID # B1Y-MC-X143. We also want to thank the LSUHSC IRB that approved this study and that has encouraged our research in child and adolescent psychiatry.

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Authors and Affiliations

  1. Department of Psychiatry, Louisiana State University Health Sciences Center School of Medicine at New Orleans, 1542 Tulane Avenue, New Orleans, LA, 70112, USA

    Humberto Quintana, Grant J. Butterbaugh, William Purnell & Ann K. Layman

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  1. Humberto Quintana
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  2. Grant J. Butterbaugh
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  3. William Purnell
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  4. Ann K. Layman
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Correspondence to Humberto Quintana.

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Quintana, H., Butterbaugh, G.J., Purnell, W. et al. Fluoxetine Monotherapy in Attention-Deficit/Hyperactivity Disorder and Comorbid Non-Bipolar Mood Disorders in Children and Adolescents. Child Psychiatry Hum Dev 37, 241–253 (2007). https://doi.org/10.1007/s10578-006-0032-7

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  • DOI: https://doi.org/10.1007/s10578-006-0032-7

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