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Gender-Specific Association Between ACE Gene I/D Polymorphism and Blood Pressure Response to Hydrochlorothiazide in Han Chinese Hypertensive Patients

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Abstract

To evaluate the interaction between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and gender with individual blood pressure response to hydrochlorothiazide (HCTZ) in hypertensives, we enrolled 829 mild-moderate hypertensive patients. All subjects were given HCTZ (12.5 mg) orally each day for 6 weeks. A total of 776 patients completed the study. There was statistically significant interaction between the effects of genotype and gender on systolic (P = 0.002) and diastolic (P = 0.048) response after adjusting for covariables. Moreover, in each gender, the genotype that was associated with the greatest blood pressure response to HCTZ (DD homozygotes in men and II homozygotes in women) was also associated with the greatest increase in serum ACE activity in response to HCTZ. The results suggest that the I/D polymorphism of the ACE gene is associated with interindividual differences in the blood pressure response to a low dose of a diuretic in a gender-specific manner in the Han Chinese population with hypertension.

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Authors and Affiliations

  1. School of Public Health, Hebei United University, 57 Jianshe Rd (South), Tangshan, 063007, China

    Yun Li, Juxiang Yuan, Ying Wu, Dandan Zhao, Qi Ren, Fumin Feng & Weijun Guan

  2. Department of Neurosurgery, Affiliated Hospital of Hebei United University, Tangshan, China

    Peng Yang

  3. Department of Cardiology, Kailuan Hospital, Tangshan, China

    Shouling Wu

  4. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China

    Chong Shen

Authors
  1. Yun Li
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  2. Peng Yang
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  3. Shouling Wu
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  4. Juxiang Yuan
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  5. Chong Shen
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  6. Ying Wu
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  7. Dandan Zhao
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  8. Qi Ren
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  9. Fumin Feng
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  10. Weijun Guan
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Correspondence to Yun Li.

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Li, Y., Yang, P., Wu, S. et al. Gender-Specific Association Between ACE Gene I/D Polymorphism and Blood Pressure Response to Hydrochlorothiazide in Han Chinese Hypertensive Patients. Biochem Genet 49, 704–714 (2011). https://doi.org/10.1007/s10528-011-9444-6

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  • DOI: https://doi.org/10.1007/s10528-011-9444-6

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