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SIRT6, a protein with many faces

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Abstract

Sirtuins are NAD+ dependent deacylases enzymes. There are seven mammalian sirtuins, SIRT1–SIRT7, which are localized to different cellular compartments and are capable of diverse catalytic activities. SIRT6 is a key regulator of healthy ageing. In the past decade our understanding of SIRT6 significantly increased in many different aspects. We know its cellular localization, catalytic activities, substrates and the pathways it is involved in. This review discusses the recent discoveries regarding the SIRT6 enzyme.

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Acknowledgments

We thank the members of Cohen’s lab, in particular Shoshana Naiman, for their helpful comments on the manuscript. The research at Cohen’s lab is supported by the Israel Science Foundation, Teva Pharmaceutical Industries LTD, I-Core Foundation, Israeli Ministry of Health, and the ERC: European Research Council.

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  1. The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat-Gan, Israel

    Asaf A. Gertler & Haim Y. Cohen

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  1. Asaf A. Gertler
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  2. Haim Y. Cohen
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Correspondence to Haim Y. Cohen.

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Gertler, A.A., Cohen, H.Y. SIRT6, a protein with many faces. Biogerontology 14, 629–639 (2013). https://doi.org/10.1007/s10522-013-9478-8

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  • DOI: https://doi.org/10.1007/s10522-013-9478-8

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