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Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice

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Abstract

The decline in physical performance with increasing age is a crucial problem in our aging society. We examined the effects of resveratrol, a natural polyphenolic compound present in grapes, in combination with habitual exercise on the aging-associated decline in physical performance in senescence-accelerated prone mice (SAMP1). The endurance capacity of SAMP1 mice undergoing an exercise regimen (SAMP1-Ex) decreased over 12 weeks whereas that of SAMP1 mice fed 0.2% (w/w) resveratrol along with exercise (SAMP1-ExRes) remained significantly higher. In the SAMP1-ExRes group, there was a significant increase in oxygen consumption and skeletal muscle mRNA levels of mitochondrial function-related enzymes. These results suggest that the intake of resveratrol, together with habitual exercise, is beneficial for suppressing the aging-related decline in physical performance and that these effects are attributable, at least in part, to improved mitochondrial function in skeletal muscle.

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Abbreviations

CYOX:

Cytochrome c oxidase

EDL:

Extensor digitorum longus

PGC-1:

Peroxisome proliferator-activated receptor-γ coactivator-1

SAM:

Senescence-accelerated mice

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Authors and Affiliations

  1. Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi, 321-3497, Japan

    Takatoshi Murase, Satoshi Haramizu, Noriyasu Ota & Tadashi Hase

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  1. Takatoshi Murase
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  2. Satoshi Haramizu
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  3. Noriyasu Ota
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  4. Tadashi Hase
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Correspondence to Takatoshi Murase.

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Murase, T., Haramizu, S., Ota, N. et al. Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice. Biogerontology 10, 423–434 (2009). https://doi.org/10.1007/s10522-008-9177-z

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