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Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein

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Abstract

The importance of the dipeptidyl peptidase 4 (DPP4) gene family in regulating critical biochemical pathways continues to emerge. The two most well-studied members of the family, DPP4 and fibroblast activation protein (FAP), have been investigated both as therapeutic targets for disease and as diagnostic biomarkers. The interest in DPP4 and FAP as potential disease biomarkers has been driven primarily by observations of altered expression profiles in inflammatory diseases and cancer. Furthermore, the stability and persistence of soluble DPP4 and FAP in the serum make them attractive candidate serology markers. This review summarises investigations into DPP4 and FAP as biomarkers of autoimmune disease, gut inflammation, psychosomatic disorders and malignancy and discusses their potential likelihood as clinically useful tools.

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Acknowledgements

Dr. Yazbeck is supported by the Catherine Marie Enright Kelly cancer research fellowship within the Flinders University Department of Surgery.

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Authors and Affiliations

  1. Department of Surgery, College of Medicine and Public Health, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia

    Roger Yazbeck & Simone E. Jaenisch

  2. Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, South Australia, Australia

    Roger Yazbeck, Simone E. Jaenisch & Catherine A. Abbott

  3. College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia

    Catherine A. Abbott

Authors
  1. Roger Yazbeck
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  2. Simone E. Jaenisch
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  3. Catherine A. Abbott
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Correspondence to Catherine A. Abbott.

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The authors declare that they have no conflict of interest.

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Yazbeck, R., Jaenisch, S.E. & Abbott, C.A. Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein. Protoplasma 255, 375–386 (2018). https://doi.org/10.1007/s00709-017-1129-5

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  • DOI: https://doi.org/10.1007/s00709-017-1129-5

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