Abstract
The standard therapy of hydatid cyst is surgery but, in nonoperable patients and multiple organ involvement, medical therapy may be more useful. The efficacy of drugs especially in short-term treatment of hydatid cyst is unknown. This study was carried out to evaluate the effect of combination therapy with albendazole and praziquantel in the treatment of hydatid diseases. In a nonrandomized quasi-experimental study, nine patients with multiple hydatid cysts were treated with albendazole (400 mg/twice a day) and praziquantel (40 mg/kg per day) twice a week for 4 weeks. This regimen was repeated for three courses with a 2-week interval between each one. The average follow-up period after treatment was 18 months. Response to treatment was assessed through the observation of the symptoms and radiologic findings (computed axial tomography scan, sonography, X-ray). Symptoms disappeared in seven (77.8%) patients and improved partially in two (22.2%) patients. Radiological assessment showed significant improvement in five (55.6%) and partial improvement in four (44.4%) patients. Combination therapy with albendazole and praziquantel is effective in the treatment of hydatid cyst and can be used as an alternative to surgery in disseminated and nonoperable cases.
Similar content being viewed by others
References
Amir-Jahed AK, Fardin R, Farzad A, Bakshandeh K (1975) Clinical echinococcosis. Ann Surg 182:541–546
Anadol D, Özçelik U, Kiper N, Göçmen A (2001) Treatment of hydatid disease. Paediatr Drugs 3:123–135
EL-On J (2002) Benzimidazole treatment of cystic echinococcosis. Acta Trop 85:243–252
King CH (2000) Echinococcosis. In: Mandell GL, Bennett JE, Dolin R (eds) Principles and practice of infectious disease. 5th edn. Churchill Livingstone, Philadelphia, pp 515–527
Moreno MJ, Urrea-París MA, Casado N, Rodriguez-Caabeiro F (2001) Praziquantel and albendazole in the combined treatment of experimental hydatid disease. Parasitol Res 87:235–238
Morris DL, Richards KS, Clarkson MJ, Taylor DH (1990) Comparison of albendazole and praziquantel therapy of Echinococcus granulosus in naturally infected sheep. Vet Parasitol 36:83–90
Nutman TB, Weller PF (2001) Echinococcosis. In: Harrison TR, Braunwald E (eds) Harrison’s principles of internal medicine. 15th edn. McGraw-Hill, New York, pp 478–482
Taylor DH, Morris DL, Reffin D, Richards KS (1989) Comparison of albendazole, mebendazole and praziquantel chemotherapy of Echinococcus multilocularis in a gerbil model. Gut 30:1401–1405
Teggi A, Lastilla MG, De Rosa F (1993) Therapy of human hydatid disease with mebendazole and albendazole. Antimicrob Agents Chemother 37:1670–1689
Urrea-Paris MA, Moreno MJ, Cusado N (2000) In vitro effect of praziquantel and albendazole combination therapy on the larval stage of Echinococcus granulosus. Parasitol Res 86:957–964
Yasawy MI, al Karawi MA, Mohamed AR (1993) Combination of praziquantel and albendazole in the treatment of hydatid disease. Trop Med Parasitol 44:192–194
Yasawy MI, Alkarawi MA, Mohammad AR (2001) Prospects in medical management of Echinococcus granulosus. Hepatogastroentrerology 48:1467–1470
Acknowledgment
The author would like to thank Farzan Institute for Research and Technology for technical assistance.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jamshidi, M., Mohraz, M., Zangeneh, M. et al. The effect of combination therapy with albendazole and praziquantel on hydatid cyst treatment. Parasitol Res 103, 195–199 (2008). https://doi.org/10.1007/s00436-008-0954-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00436-008-0954-z