Abstract
The efficacy of 5-chloro-2-methylthio-6-(1-napthyloxy)-1H-benzimidazole was evaluated with three commercial fasciolicides in terms of the percentage of egg reduction in cattle. Fifty Swiss cows were selected for inclusion in the trial based on finding eggs of Fasciola hepatica in their feces. On day 0, they were blocked in five groups (G) of ten animals each according to fecal egg counts. G1 received compound alpha at 12 mg/kg p.o.; G2 triclabendazole at 12 mg/kg p.o.; G3.closantel at 3.5 mg/kg s.c.; G4 clorsulon at 2.0 mg/kg s.c. G5 animals served as untreated controls. Fecal analysis was performed on days 0, 7, 14, 21, 28, 60 and 90. Efficacy was measured on days 14 and 21. In addition, the extension and intensity effects were determined on day 60. The percentage efficacy for groups 1–4 was 98.1, 98.7, 98.2 and 97.9 on day 14 and 98.5, 97.9, 97.7 and 97.9 on day 21, respectively. No statistical differences were observed between treated groups.
Similar content being viewed by others
References
Besvir J, Rapic D, Dzakula N, Blagovic S, Pompe-Gotal J (1986) Fasinex (triclabendazole)–new fasciolicide. Praxis Vet 34:239–242
Cordero del Campillo M, Rojo Vázquez FA (1999) Parasitología veterinaria. McGraw-Hill Interamericana, Madrid
Dorchies PF, Ducos de Lahitte J (1983) Study on the activity of triclabendazole (DCI) against Fasciola hepatica in lambs. Rev Med Vet 134:231–234
Echevarría FAM, Correa MBC, Wherle RD, Correa IF (1992) Experiments on anthelmintics control of Fasciola hepatica in Brazil. Vet Parasitol 43:211–222
Eckert J, Schneiter G, Wolf K (1984) Fasinex (Triclabendazole)-ein neues Fazciolizide. Berl Munch Tierarztl Wochenschr 91:249–356
Hernández CA, Ibarra VF, Vera MY, Rivera FN, Castillo BR (2002) Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole. Chem Pharm Bull 50:649–652
Ibarra VF, Vera Montenegro Y (1991) Comparación del efecto extensivo de 5 fasciolicidas en bovinos en clima cálido. Vet Mex 22:159–163
Ibarra VF, Quiróz RH, Pérez THJ, Vera MY, Tello RM (1987) Determinación de la extensión del efecto de Triclabendazol, Rafoxanide, Nitroxinil y Meniclofolan en bovinos infectados en forma natural con Fasciola hepatica. Tec Pecu Mex 25:404–408
Ibarra VF, García SE, Fernández RM, Vera MY, Hernández CA, Castillo BR (1997a) Eficacia de dos compuestos de síntesis química in vitro e in vivo en ovinos. Vet Mex 28:291–296
Ibarra VF, Vera MY, Hernández CA, Castillo BR (1997b) Eficacia fasciolicida del compuesto Alfa contra estadios juveniles y adultos en ovinos. Vet Mex 28:297–301
Ibarra VF, Vera MY, Montenegro CN, Flores CJ, Hernández CA, Castillo BR (2000) Evaluación de cuatro vehículos para formular un fasciolicida experimental. Vet Mex 31:47–51
Ibarra VF, Vera MY, Nájera FR, Sánchez AA (2001) Efficacy of combined chemotherapy against gastrointestinal nematodes and Fasciola hepatica in cattle. Vet Parasitol 99:199–204
Ministry of Agriculture, Fisheries and Food (1988) Manual of veterinary larasitological laboratory techniques, Technical Bulletin No. 18. Her Majesty´s Stationery Office, London
Montgomery D (1984) The design and analysis of experiments, 2nd edn. Williams, New York
Quiroz RH (1997) Parasitología y enfermedades parasitarias de animales domésticos, 7th edn. Limusa, México City
Rapic D, Dzakula A, Sakar D, Richards RJ (1998) Comparative efficacy of triclabendazole, nitroxinil and rafoxanide against immature and mature Fasciola hepatica in naturally infected cattle. Vet Rec 122:59–62
Rivera FN, Ibarra VF, Olazarán JS, Vera MY, Castillo BR, Hernández CA (2002) Eficacia del 5-cloro-2-metiltio-6-(1-naftiloxy)-1H-benzimidazol contra diversas edades de Fasciola hepatica en ovinos. Vet Mex 33:55–61
Shin-Sung S, Lee-Chung G, Cho-Shinn H, Kim-Jong T, Wee-Sung S, Shin S (1995) Efficacy of closantel for the treatment of naturally-acquired and experimentally induced Fasciola hepatica infections in cattle Korean J Vet Res 35:347–352
Statistical Analysis Systems (1990) User's guide, 4th edn. SAS/STAT, Cary
Wallace DH, Kilgore RI, Benz GW (1985) Clorsulon: a new fasciolicide for cattle. Mod Vet Pract 66:879–882
Wood IB, Amaral NK, Bairden K, Duncan JL, Kassai J, Malone JB, Pankavich JA, Reinecke RK, Slocombe O, Taylor SM, Vercruysse J (1995) World Association for the Advancement of Veterinary Parasitology Guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine and caprine), 2nd edn. Vet Parasitol, 58:181–213
Zar JH (1996) Biostatistical analysis, 3rd edn. Prentice Hall, Upper Saddle River
Acknowledgements
The authors thank Dr. Marco Antonio Hidalgo from rancho "Copalar" for the use of facilities. The study was partially supported by CONACYT, Mexico, Project no. 34942-B. These experiments comply with the current laws of Mexico.
Author information
Authors and Affiliations
Corresponding author
Additional information
Taken in part from the PhD thesis of Yolanda Vera Montenegro
Rights and permissions
About this article
Cite this article
Vera Montenegro, Y., Ibarra Velarde, F., Quiroz Romero, H. et al. Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle. Parasitol Res 91, 1–4 (2003). https://doi.org/10.1007/s00436-003-0901-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00436-003-0901-y