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Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer

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Abstract

Purpose

Improved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224–2229, 6), and preserved immunity was suggested as the reason for the survival advantage. The aim of our study was to clarify the existence of an immunological benefit after laparoscopic colon cancer surgery (LC) compared to open colon surgery (OC).

Methods

From January 2006 to November 2007, 74 patients with clinical stage III colon cancer were prospectively assigned to undergo a LC (n = 35) or an OC (n = 39). The immune factors were examined preoperatively, and on the first and fifth days postoperatively (POD1 and POD5).

Results

The cellular immune factors were significantly decreased; however, there was no significant difference between the LC and OC groups except for the mHLA-DR. The LC group had a better preserved mHLA-DR on POD5 than did the OC group (p = 0.015), in addition to a faster recovery (p < 0.005).

Conclusion

The mHLA-DR on POD5 was affected less by the LC compared to the OC. The LC demonstrated minimal immunological advantage when compared to the OC. However, further study is required to clarify the immunological benefits of the LC on colorectal cancer prognosis.

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Acknowledgment

This study was supported by the Samsung Medical Center Clinical Research Development Program grant, #CRS-106-14-1.

This article was presented at 2008 EAES conference and awarded as the best poster.

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Authors and Affiliations

  1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong #50, Gangnam-gu, Seoul, Korea, 135-710

    Sang-Ah Han, Woo Yong Lee, Chi-Min Park, Seong Hyeon Yun & Ho-Kyung Chun

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  1. Sang-Ah Han
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  2. Woo Yong Lee
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Correspondence to Woo Yong Lee.

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Han, SA., Lee, W.Y., Park, CM. et al. Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer. Int J Colorectal Dis 25, 631–638 (2010). https://doi.org/10.1007/s00384-010-0882-0

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  • DOI: https://doi.org/10.1007/s00384-010-0882-0

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