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Mapping to Chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens

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References

  1. Rowe L, Nadeau J, Turner R, Frankel W, Letts V, Eppig J, Ko M, Thurston S, Birkenmeier E (1994) Maps from two interspecific back-cross DNA panels as a community mapping resource. Mammal Genome 5, 253–274

    Article  CAS  Google Scholar 

  2. Rabin DU, Pleasic SM, Shapiro JA, Yoowarren H, Oles J, Hicks JM, Goldstein DE, Rae PMM (1994) Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152, 3183–3188

    PubMed  CAS  Google Scholar 

  3. Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS (1996) Identification of a second transmembrane protein tyrosine phosphatase, IA-2 beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci USA 93, 2307–2311

    Article  PubMed  CAS  Google Scholar 

  4. Lan M, Modi W, Xie H, Notkins A (1996) Assignment of the IA-2 gene encoding an autoantigen in IDDM to chromosome 2q35. Diabetologia 39, 1001–1002

    Article  PubMed  CAS  Google Scholar 

  5. Smith P, Barker K, Wang J, Lu Y-J, Shipley J, Cromptom M (1996) ICAAR, a novel member of a new family of transmembrane tyrosine phosphatase-like proteins. Biochem Biophys Res Commun 229, 402- 411

    Article  PubMed  CAS  Google Scholar 

  6. Mackay M, Fantes J, Scherer S, Boyle S, West K, Tsui L-C, Belloni E, Lutz E, Van Heyningen V, Harmar A (1996) Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype. Genomics 37, 345–353

    Article  PubMed  CAS  Google Scholar 

  7. Zhao Z, Lee C-C, Mockton D, Yazdani A, Coolbaugh M, Li X, Bailey J, Shen Y, Caskey C (1996) Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. Genomics 35, 172–181

    Article  PubMed  CAS  Google Scholar 

  8. Lan M, Lu J, Goto Y, Notkins A (1994) Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13, 505–514

    Article  PubMed  CAS  Google Scholar 

  9. Notkins A, Lu J, Li Q, VanderVegt F, Wasserfall C, Maclaren N, Lan M (1996) IA-2 and IA-2β are major autoantigens in IDDM and the precursors of the 40 KDA and 37 KDA tryptic fragments. J Autoimmum 9, 677–682

    Article  CAS  Google Scholar 

  10. Pietropaolo M, Hutton J, Eisenbarth G (1997) Protein-tyrosine phosphatase-like proteins—link with IDDM. Diabetes Care 20, 208–214

    PubMed  CAS  Google Scholar 

  11. Magistrelli G, Covini N, Mosca M, Lippoli G, Isacchi A (1995) Expression of PTP35, the murine homologue of the protein tyrosine phosphatase-related sequence IA-2, is regulated during cell growth and stimulated by mitogens in 3T3 fibroblasts. Biochem Biophys Res Commun 217, 154–161

    Article  PubMed  CAS  Google Scholar 

  12. Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall RJ, Prins J-B, McShane P, Lathrop GM, Peterson LB, Wicker LS, Todd JA (1993) Polygenic control of autoimmune diabetes in non-obese diabetic mice. Nature Genet 4, 404–409

    Article  PubMed  CAS  Google Scholar 

  13. DeSilva M, Jun H, Yoon J, Notkins A, Lan M (1996) Autoantibodies to IA-2 not detected in NOD mice or BB rats. Diabetologia 39, 1237- 1238

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Jackson Laboratory, 04609-1500, Bar Harbor, Maine, USA

    Edward H. Leiter, Hideki Tsumura, David V. Serreze & Harold D. Chapman

  2. Bayer Research Center, 06516, West Haven, Connecticut, USA

    Daniel U. Rabin

  3. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, 20892, Bethesda, Maryland, USA

    Michael S. Lan & Abner L. Notkins

Authors
  1. Edward H. Leiter
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  2. Hideki Tsumura
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  3. David V. Serreze
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  4. Harold D. Chapman
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  5. Daniel U. Rabin
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  6. Michael S. Lan
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  7. Abner L. Notkins
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Leiter, E.H., Tsumura, H., Serreze, D.V. et al. Mapping to Chromosomes 1 and 12 of mouse homologs of human protein tyrosine phosphatase, receptor-type, related genes encoding pancreatic beta cell autoantigens. Mammalian Genome 8, 949–950 (1997). https://doi.org/10.1007/s003359900619

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  • DOI: https://doi.org/10.1007/s003359900619

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