Abstract
In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.
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Acknowledgment
This work was supported by the U.S. National Institutes of Health through the following grants: R01AR046530 (CHT), P01AG018397 (CHT, DLK, TF, MJE), RO1 AR47866, and RO1 AR42228 (MJE).
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Koller, D.L., Alam, I., Sun, Q. et al. Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains. Mamm Genome 16, 578–586 (2005). https://doi.org/10.1007/s00335-004-2459-0
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DOI: https://doi.org/10.1007/s00335-004-2459-0