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Lymphome der Milz

Lymphomas of the spleen

  • Schwerpunkt: Pathologie der Milz
  • Published:
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Zusammenfassung

Die Milz kann von fast allen Typen maligner Lymphome im Sinne einer Mitbeteiligung befallen werden, wobei die makroskopische Verteilung der Infiltrate Hinweise auf die zugrunde liegende Lymphomentität geben kann. Zumeist werden Lymphome jedoch nicht am Splenektomiepräparat diagnostiziert. Zu den Lymphomen, bei denen die histologischen Befunde der Milz diagnostisch sind, zählen das splenische Marginalzonenlymphom und das hepatosplenische T-Zell-Lymphom. Typisch ist auch die Milzbeteiligung bei Haarzellleukämie, Leukämie der großen granulären Lymphozyten und bei der T-Zell-Prolymphozyten-Leukämie. Diese Tumoren haben jeweils charakteristische Infiltrationsmuster in der Milz, die ausführlich diskutiert werden.

Abstract

The spleen is commonly affected by malignant lymphomas and the macroscopic findings of the spleen correlate with different lymphoma entities. However, most lymphomas are not primarily diagnosed in splenectomy specimens. Exceptions include splenic marginal zone lymphomas and hepatosplenic T-cell lymphomas that are typically diagnosed from histological findings. In addition, hairy-cell leukemia, LGL leukemia and T-cell prolymphocytic leukemia typically show characteristic patterns of infiltration in the spleen which may be diagnostically useful. The different infiltration patterns of these tumors are discussed here.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsklinikum Mannheim, Mannheim, Deutschland

    A. Marx

  2. Institut für Pathologie, Universität Würzburg, Würzburg, Deutschland

    H.K. Müller-Hermelink, E. Geißinger, A. Zettl & P. Adam

  3. Institut für Pathologie, Städtisches Klinikum Karlsruhe, Moltkestraße 90, 76133, Karlsruhe, Deutschland

    M. Hartmann &  T. Rüdiger

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  1. A. Marx
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  2. H.K. Müller-Hermelink
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  3. M. Hartmann
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  4. E. Geißinger
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  5. A. Zettl
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  6. P. Adam
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  7. T. Rüdiger
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Correspondence to T. Rüdiger.

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Marx, A., Müller-Hermelink, H., Hartmann, M. et al. Lymphome der Milz. Pathologe 29, 136–142 (2008). https://doi.org/10.1007/s00292-008-0976-4

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  • DOI: https://doi.org/10.1007/s00292-008-0976-4

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