Zusammenfassung
Sinonasale maligne periphere Nervenscheidentumoren (MPNST) sind selten. Aus dem in Jena geführten Register für Weichgewebstumoren werden 16 Fälle S100-Protein-positiver niedrig-maligner MPNST der Nasen- und Nasennebenhöhlenregion vorgestellt. Die Bedeutung einer nur partiellen Immunfärbung der Tumorzellen durch S100-Protein-Antikörper für die Diagnose und differenzialdiagnostische Abgrenzung gegenüber gutartigen Nervenscheidentumoren (Schwannome und Neurofibrome) wird herausgearbeitet. Ergänzend erfolgt eine kurze Darstellung der Differenzialdiagnose von Spindelzelltumoren im Sinonasalbereich.
Abstract
Sinonasal malignant peripheral nerve sheath tumors (MPNST) are infrequent neoplasms. 16 cases of low-malignant MPNST in this localization were retrieved from the files of soft tissue tumors established in Jena. They were examined with regard to their morphology and immunohistochemistry. The importance of an only partial immunostaining by S100 protein antibodies for diagnosis and differential diagnostic discrimination to benign peripheral nerve sheath tumors (schwannomas and neurofibromas) is explained. Finally, the differential diagnosis of spindle cell tumors in the sinonasal region in general is briefly discussed.
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Danksagung
Folgenden Kollegen sei an dieser Stelle für die Einsendung von Untersuchungsmaterial herzlich gedankt:
Dr. Bergholz (Wolfsburg), Dr. Born (Heidelberg), Prof. Dr. Bosse (Stuttgart), Dr. Feuerhake (Freiburg) Dr. Günzel (Chemnitz), Dr. Krafft (Ulm), Dr. Kupsch (Braunschweig), Prof. Dr. Lorenz (Greifswald), Priv.-Doz. Dr. Lorenzen (Köln), Dr. Meyling (Bremen), Dr. Niemann (Hamm), Dr. Schwabbauer (Neubrandenburg), Dr. Völker (Erlangen), Priv.-Doz. Dr. Wehrmann (Tübingen), Dr. Westenfelder-Dücker (Neuss).
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Katenkamp, K., Katenkamp, D. Niedrig-maligne periphere Nervenscheidentumoren der Nasen- und Nasennebenhöhlenschleimhaut. Pathologe 26, 90–95 (2005). https://doi.org/10.1007/s00292-004-0739-9
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DOI: https://doi.org/10.1007/s00292-004-0739-9