Abstract.
The effect of several Campylobacter jejuni strains on the immune response was analyzed in mice after intraperitoneal inoculation with 1010 colony forming units (CFU). Three C. jejuni strains were assayed: CCUG 6968 (enterotoxigenic), CCUG 7580 (enterotoxigenic), and CCUG 7440 (non-enterotoxigenic). These C. jejuni strains induced a peritoneal inflammatory response and an important increase in the peritoneal phagocyte oxidative activity measured by chemiluminescence assay, as well as an increase in the number of peritoneal cells. Both interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) production by peritoneal cells were not modified. However, C. jejuni 7440 caused a statistically significant increase in TNFα production. These results have demonstrated that different strains of C. jejuni induce an increase of the inflammatory response without a significant cytokine release. However, these infectious microorganisms may be eliminated efficiently by murine macrophages after phagocytosis.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 18 February 1999 / Accepted: 6 May 1999
Rights and permissions
About this article
Cite this article
Pancorbo, P., de Pablo, M., Ortega, E. et al. Evaluation of Cytokine Production and Phagocytic Activity in Mice Infected with Campylobacter jejuni . Curr Microbiol 39, 129–133 (1999). https://doi.org/10.1007/s002849900433
Issue Date:
DOI: https://doi.org/10.1007/s002849900433