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Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome

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Abstract

We report a female case of sinusoidal obstruction syndrome (SOS) diagnosed pathologically after chemotherapy (Pmab+m-FOLFOX6) for ascending colon cancer with multiple liver metastases, focusing on the findings of gadoxetic acid-enhanced MRI (EOB-MRI) and the organic anion transporting polypeptide 1B3 (OATP1B3) expression of in the liver. The patient was a 75-year-old female. She had received chemotherapy (Pmab+m-FOLFOX6) as six cycles for preoperative chemotherapy. After the preoperative chemotherapy, tumor sizes of hepatic metastases were reduced and hepatobiliary phase of EOB-MRI clearly depicted diffuse reticular hypointensity in the background liver. On the other hand, dynamic CT and/or other sequences of EOB-MRI did not show definite abnormality in the background liver. After the operation, this patient was pathologically confirmed as SOS demonstrating centrilobular congestion, sinusoidal dilatation, and perisinusoidal fibrosis. In normal liver parenchyma, OATP1B3 (uptake transporter of the EOB-MRI) expression is observed predominantly in centrilobular hepatocytes (zone 3). On the other hand, OATP1B3 expression was remarkably reduced because of the damages in the centrilobular (zone 3) hepatocytes in this SOS case. This indicated that EOB-MRI might be extremely sensitive in diagnosing SOS in its early stage.

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Authors and Affiliations

  1. Department of Radiology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan

    Norihide Yoneda, Osamu Matsui, Hiroshi Ikeno, Dai Inoue, Kotaro Yoshida, Azusa Kitao, Kazuto Kozaka, Satoshi Kobayashi & Toshifumi Gabata

  2. Division of Pathology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan

    Hiroko Ikeda

  3. Department of Gastroenterologic Surgery, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan

    Keishi Nakamura & Tetsuo Ohta

Authors
  1. Norihide Yoneda
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  2. Osamu Matsui
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  3. Hiroshi Ikeno
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  4. Dai Inoue
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  5. Kotaro Yoshida
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  6. Azusa Kitao
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  7. Kazuto Kozaka
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  8. Satoshi Kobayashi
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  9. Toshifumi Gabata
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  10. Hiroko Ikeda
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  11. Keishi Nakamura
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  12. Tetsuo Ohta
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Correspondence to Norihide Yoneda.

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Yoneda, N., Matsui, O., Ikeno, H. et al. Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome. Abdom Imaging 40, 3099–3103 (2015). https://doi.org/10.1007/s00261-015-0503-z

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  • DOI: https://doi.org/10.1007/s00261-015-0503-z

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