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TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development

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Abstract

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease. Although genetic factors confer susceptibility to the disease, only 15 % of the genetic contribution has been identified. TRAF3IP2 gene, associated with susceptibility to psoriatic arthritis and psoriasis, encodes for Act1, a negative regulator of adaptive immunity and a positive signaling adaptor in IL-17-mediated immune responses. The aim of this study was to assess the role of TRAF3IP2 gene variability in SLE susceptibility and disease phenotype in an Italian population. Two hundred thirty-nine consecutive SLE patients were enrolled. Study protocol included complete physical examination; the clinical and laboratory data were collected. Two hundred seventy-eight age- and ethnicity-matched healthy subjects served as controls. TRAF3IP2 polymorphisms (rs33980500, rs13190932, and rs13193677) were analyzed in both cases and controls. Genotype analysis was performed by allelic discrimination assays. A case–control association study and a genotype–phenotype correlation were performed. The rs33980500 and rs13193677 resulted significantly associated with SLE susceptibility (P = 0.021, odds ratio (OR) = 1.71, and P = 0.046, OR = 1.73, respectively). All three TRAF3IP2 single nucleotide polymorphisms resulted associated with the development of pericarditis; in particular, rs33980500 showed the strongest association (P = 0.002, OR 2.59). This association was further highlighted by binary logistic regression analysis. In conclusion, our data show for the first time the contribution of TRAF3IP2 genetic variability in SLE susceptibility, providing further suggestions that common variation in genes that function in the adaptive and innate arms of the immune system are important in establishing SLE risk. Our study also shows that this gene may affect disease phenotype and, particularly, the occurrence of pericarditis.

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The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Lupus Clinic, Reumatologia, Dipartimento di Clinica e Terapia Medica, Sapienza Università di Roma, Rome, Italy

    Carlo Perricone, Fulvia Ceccarelli, Francesca Romana Spinelli, Enrica Cipriano, Guido Valesini & Fabrizio Conti

  2. Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome “Tor Vergata”, Rome, Italy

    Cinzia Ciccacci, Davide Di Fusco, Giuseppe Novelli & Paola Borgiani

  3. Department of Biomedicine and Prevention, Genetics Section, University of Rome “Tor Vergata”, 00133, Rome, Italy

    Cinzia Ciccacci

Authors
  1. Carlo Perricone
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  2. Cinzia Ciccacci
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  3. Fulvia Ceccarelli
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  4. Davide Di Fusco
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  5. Francesca Romana Spinelli
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  6. Enrica Cipriano
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  7. Giuseppe Novelli
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  8. Guido Valesini
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  9. Fabrizio Conti
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  10. Paola Borgiani
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Correspondence to Cinzia Ciccacci.

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CP and CC contributed equally to this work

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Perricone, C., Ciccacci, C., Ceccarelli, F. et al. TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development. Immunogenetics 65, 703–709 (2013). https://doi.org/10.1007/s00251-013-0717-6

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  • DOI: https://doi.org/10.1007/s00251-013-0717-6

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