Abstract
Objectives
To determine the prevalence of inappropriate medication prescribing in Middle Eastern community-dwelling elderly persons, and to determine factors associated with inappropriate prescribing.
Methods
Prescriptions from 3,000 elderly-patient visits (≥65 years) to physicians in Isfahan, Iran were collected between September and December 2002; only the first patient visit was considered in the study. Inappropriate prescriptions were defined according to Beers’ explicit criteria (1997). The presence of at least one drug–drug interaction (DDI) and at least one drug-class duplication within each patient visit was also determined. Multivariate analyses were performed to determine factors associated with receiving at least one inappropriate medication. These factors included age, gender, number of prescribed medications per visit, DDIs, duplications, and physician’s number of years of experience. Similar analyses were performed to determine whether these factors were associated with a composite index (defined as having at least one of the following: receiving at least one inappropriate prescription, DDI, or duplication).
Results
The mean age of our cohort was 72.6 (±5.7) years, and 1,735 (57.8%) were females. A total of 829 (27.6%) patients received at least one inappropriate prescription, 285 (9.5%) had at least one DDI during the visit, and 746 (24.9%) had at least one duplication during the visit. The three most inappropriately prescribed medication classes were antihistamines (29%), non-steroidal anti-inflammatory agents (23%) and benzodiazepines (16%). In multivariate analyses, the number of prescribed medications per visit was the only factor significantly associated with receiving at least one inappropriate prescription (OR 1.24; 95%CI: 1.16–1.32); analyses using the composite index as outcome gave similar results (OR: 1.70; 95%CI: 1.60–1.80).
Conclusion
Our findings indicate a high prevalence of inappropriate prescribing in elderly patients. Given the potential severity of this problem, further steps need to be implemented to prevent this occurrence.
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References
Bates DW (1998) Drugs and adverse drug reactions: how worried should we be? JAMA 279:1216–1217
Everitt DE, Avorn J (1986) Drug prescribing for the elderly. Arch Intern Med 146:2393–2396
Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC (1991) Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med 151:1825–1832
Stuck AE, Beers MH, Steiner A, Aronow HU, Rubenstein LZ, Beck JC (1994) Inappropriate medication use in community-residing older persons. Arch Intern Med 154:2195–2200
Gupta S, Rappaport HM, Bennett LT (1996) Inappropriate drug prescribing and related outcomes for elderly Medicaid beneficiaries residing in nursing homes. Clin Ther 18:183–196
Spore DL, Mor V, Larrat P, Hawes C, Hiris J (1997) Inappropriate drug prescriptions for elderly residents of board-and-care facilities. Am J Public Health 87:404–409
Golden AG, Preston RA, Barnett SD, Llorente M, Hamdan K, Silverman MA (1999) Inappropriate medication prescribing in homebound older adults. J Am Geriatr Soc 47:948–953
Meredith S, Feldman PH, Frey D, Hall K, Arnold K, Brown NJ, Ray WA (2001) Possible medication errors in home healthcare patients. J Am Geriatr Soc 49:719–724
Spiker EC, Emptage RE, Giannamore MR, Pedersen CA (2001) Potential adverse drug events in an indigent and homeless geriatric population. Ann Pharmacother 35:1166–1172
Chin MH, Wang LC, Jin L, Mulliken R, Walter J, Hayley DC, Karrison TG, Nerney MP, Miller A, Friedmann PD (1999) Appropriateness of medication selection for older persons in an urban academic emergency department. Acad Emerg Med 6:1232–1242
Beers MH (1997) Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med 157:1531–1536
Willcox SM, Himmelstein DU, Woolhandler S (1994) Inappropriate drug prescribing for the community-dwelling elderly. JAMA 272:292–296
Zhan C, Sangl J, Bierman AS, Miller MR, Friedman B, Wickizer SW, Meyer GS (2001) Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA 286:2823–2829
Laurier C, Moride Y, Kennedy WA (2002) Health survey data on potentially inappropriate geriatric drug use. Ann Pharmacother 36:404–409
Onder G, Landi F, Cesari M, Gambassi G, Carbonin P, Bernabei R (2003) Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly. Eur J Clin Pharmacol 59:157–162
Pitkala KH, Strandberg TE, Tilvis RS (2002) Inappropriate drug prescribing in home-dwelling, elderly patients: a population-based survey. Arch Intern Med 162:1707–1712
Straand J, Rokstad KS (1999) Elderly patients in general practice: diagnoses, drugs and inappropriate prescriptions. A report from the More & Romsdal Prescription Study. Fam Pract 16:380–388
Heininger-Rothbucher D, Daxecker M, Ulmer H, Gritsch W, Pechlaner C, Wiedermann CJ (2003) Problematic drugs in elderly patients presenting to a European emergency room. Eur J Intern Med 14:372–376
Bretherton A, Day L, Lewis G (2003) Polypharmacy and older people. Nurs Times 99:54–55
Gray SL, Hedrick SC, Rhinard EE, Sales AE, Sullivan JH, Tornatore JB, Curtis MP (2003) Potentially inappropriate medication use in community residential care facilities. Ann Pharmacother 37:988–993
Samsa GP, Hanlon JT, Schmader KE, Weinberger M, Clipp EC, Uttech KM, Lewis IK, Landsman PB, Cohen HJ (1994) A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity. J Clin Epidemiol 47:891–896
Schmader K, Hanlon JT, Weinberger M, Landsman PB, Samsa GP, Lewis I, Uttech K, Cohen HJ, Feussner JR (1994) Appropriateness of medication prescribing in ambulatory elderly patients. J Am Geriatr Soc 42:1241–1247
Fitzgerald LS, Hanlon JT, Shelton PS, Landsman PB, Schmader KE, Pulliam CC, Williams ME (1997) Reliability of a modified medication appropriateness index in ambulatory older persons. Ann Pharmacother 31:543–548
Aparasu RR, Fliginger SE (1997) Inappropriate medication prescribing for the elderly by office-based physicians. Ann Pharmacother 31:823–829
Aparasu RR, Sitzman SJ (1999) Inappropriate prescribing for elderly outpatients. Am J Health Syst Pharm 56:433–439
Vlahovic-Palcevski V, Bergman U (2004) Quality of prescribing for the elderly in Croatia—computerized pharmacy data can be used to screen for potentially inappropriate prescribing. Eur J Clin Pharmacol 60:217–220
Curtis LH, Ostbye T, Sendersky V, Hutchison S, Dans PE, Wright A, Woosley RL, Schulman KA (2004) Inappropriate prescribing for elderly Americans in a large outpatient population. Arch Intern Med 164:1621–1625
Lechevallier-Michel N, Gautier-Bertrand M, Alperovitch A, Berr C, Belmin J, Legrain S, Saint-Jean O, Tavernier B, Dartigues JF, Fourrier-Reglat A (2005) Frequency and risk factors of potentially inappropriate medication use in a community-dwelling elderly population: results from the 3C Study. Eur J Clin Pharmacol 60:813–819
Klarin I, Wimo A, Fastbom J (2005) The association of inappropriate drug use with hospitalisation and mortality: a population-based study of the very old. Drugs Aging 22:69–82
Ay P, Akici A, Harmanc H (2005) Drug utilization and potentially inappropriate drug use in elderly residents of a community in Istanbul, Turkey. Int J Clin Pharmacol Ther 43:195–202
Acknowledgements
This study was supported by the Research Council of Isfahan University of Medical Sciences. Laurent Azoulay is the recipient of a doctoral bursary from the Fonds de la recherche en santé du Québec. Dr. Anick Bérard is the recipient of a career award from the CIHR/Canadian Foundation for Health, and is on the endowment research Chair of the Famille Louis-Boivin on ‘Medications, Pregnancy and Lactation’ at the Faculty of Pharmacy of the University of Montreal.
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Azoulay, L., Zargarzadeh, A., Salahshouri, Z. et al. Inappropriate medication prescribing in community-dwelling elderly people living in Iran. Eur J Clin Pharmacol 61, 913–919 (2005). https://doi.org/10.1007/s00228-005-0036-4
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DOI: https://doi.org/10.1007/s00228-005-0036-4