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At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop

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References

  1. Brat DJ, Castellano-Sanchez A, Kaur B, Van Meir EG (2002) Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation. Adv Anat Pathol 9(1):24–36

    Article  PubMed  Google Scholar 

  2. Belozerov VE, Van Meir EG (2005) Hypoxia inducible factor-1: a novel target for cancer therapy. Anticancer Drugs 16(9):901–909

    Article  CAS  PubMed  Google Scholar 

  3. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M et al (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292(5516):464–468

    Article  CAS  PubMed  Google Scholar 

  4. Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3(10):721–732

    Article  CAS  PubMed  Google Scholar 

  5. Zagzag D, Zhong H, Scalzitti J, Laughner E, Simons J, Semenza G (2000) Expression of hypoxia-inducible factor 1 alpha in brain tumors: association with angiogenesis, invasion and progression. Cancer 88:2606–2618

    Article  CAS  PubMed  Google Scholar 

  6. Van Meir EG (1995) Cytokines and tumors of the central nervous system. Glia 15(3):264–288

    Article  PubMed  Google Scholar 

  7. Zhang WD, Petrovie JM, Callaghan D, Jones A, Cui H, Howlett C et al (2006) Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1 beta (IL-1 beta) in astrocyte cultures. J Neuroimmunol 174(1–2):63–73

    Article  CAS  PubMed  Google Scholar 

  8. Jung YJ, Isaacs JS, Lee SM, Trepel J, Neckers L (2003) IL-1 beta mediated up-regulation of HIF-1 alpha via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 17(12):2115–2117

    CAS  PubMed  Google Scholar 

  9. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V et al (2008) NF-kappa B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1 alpha. Nature 453(7196):807–809

    Article  CAS  PubMed  Google Scholar 

  10. Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F et al (2006) Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity. Proc Natl Acad Sci USA 103(48):18154–18159

    Article  CAS  PubMed  Google Scholar 

  11. Dey N, Durden DL, Van Meir EG (2006) Cytokine expression and signaling in brain tumors. In: Ransohoff RM, Benveniste EN (eds) Cytokines and the CNS. Taylor & Francis, Boca Raton, London, New York

    Google Scholar 

  12. Gauthier T, Hamou M-F, Monod L, Gallay P, Carrel S, de Tribolet N (1993) Expression and release of interleukin-1 by human glioblastoma cells in vitro and in vivo. Acta Neurochir 121(3–4):199–205

    Article  CAS  Google Scholar 

  13. Sharma V, Dixit D, Koul N, Mehta V, Sen E (2010) Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma. J Mol Med 89(1):1–14

    Google Scholar 

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Correspondence to Erwin G. Van Meir.

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Kaluz, S., Van Meir, E.G. At the crossroads of cancer and inflammation: Ras rewires an HIF-driven IL-1 autocrine loop. J Mol Med 89, 91–94 (2011). https://doi.org/10.1007/s00109-010-0706-2

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