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Fortschritte der endoskopischen Diagnostik von Dysplasien und Karzinomen des Larynx

Advances in endoscopic diagnosis of dysplasia and carcinoma of the larynx

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Zusammenfassung

Zur Verbesserung der prä- und intraoperativen Diagnostik des Larynxkarzinoms und seiner Vorstufen sind in den letzten Jahren verschiedene endoskopisch bildgebende Verfahren entwickelt worden. Diese Techniken unterscheiden sich deutlich in der spezifischen Anwendung und der abgeleiteten Fragestellung. Eine genaue Unterscheidung zwischen normaler Schleimhaut, Dysplasie und invasivem Karzinom durch Anwendung dieser Verfahren ist notwendig. Darüber hinaus sollte die genaue Identifikation der Tumorränder möglich sein. Langfristiges Ziel der Entwicklungen ist die optische Biopsie. Da bisher nur kleinere Studien bzgl. der Evaluation der besprochenen Techniken existieren, ist es notwendig, Multizenterstudien mit großen Fallzahlen zu etablieren, um die Wertigkeit der endoskopisch bildgebenden Verfahren genau einschätzen zu können.

Abstract

To improve the preoperative and intraoperative diagnosis of laryngeal cancer and its precursors, various endoscopic imaging techniques have been developed in recent years. These techniques differ markedly in their specific applications and goals. Precisely distinguishing among normal mucosa, dysplasia and invasive carcinoma with these procedures is necessary. Furthermore, the exact identification of tumor margins should be possible. The long-term goal is the development of optical biopsy. Since so far there have only been small studies regarding the evaluation of the presented methods, it is necessary to establish multi-center trials with large sample sizes to accurately estimate the value of these endoscopic imaging techniques.

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Authors and Affiliations

  1. Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Magdeburg A.ö.R, Leipziger Str. 44, 39120, Magdeburg, Deutschland

    C. Arens & U. Vorwerk

  2. Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universität Rostock, Rostock, Deutschland

    T. Just

  3. Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Klinikum Großhadern, Ludwig-Maximilian-Universität, München, Deutschland

    C.S. Betz

  4. Hals-, Nasen-, Ohrenklinik, Kantonsspital Aarau AG, Aarau, Schweiz

    M. Kraft

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  1. C. Arens
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  2. U. Vorwerk
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  3. T. Just
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  4. C.S. Betz
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Correspondence to C. Arens.

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Arens, C., Vorwerk, U., Just, T. et al. Fortschritte der endoskopischen Diagnostik von Dysplasien und Karzinomen des Larynx. HNO 60, 44–52 (2012). https://doi.org/10.1007/s00106-011-2428-3

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