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DieTalgdrüse als Transporter für Vitamin E

Sebaceous glands as transporters of vitamin E

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Zusammenfassung

Menschlicher Talg (Sebum) wird in der Talgdrüse produziert und entlang des Haarschafts auf die Hautoberfläche sezerniert. Neue Forschungsergebnisse zeigen, dass die Talgdrüse und ihr Sekret, Sebum, als ein physiologischer Transporter für das lipophile Antioxidans Vitamin E von der Blutzirkulation in die oberen Hautschichten dienen. Die höchsten bisher in der menschlichen Haut nachgewiesenen α-Tocopherol-Konzentrationen wurden in Sebum und den Hautoberflächenlipiden talgdrüsenreicher anatomischer Areale wie der Gesichtshaut nachgewiesen. Neuere Forschungsergebnisse weisen darauf hin, dass oral appliziertes Vitamin E bei täglicher Einnahme zu einer weiteren Anreicherung in talgdrüsenreicher Haut führt, jedoch erst nach einer täglichen Supplementierung über mindestens 3 Wochen. Demnach sind potenzielle photoprotektive und antioxidative Effekte in der Haut nach oraler Gabe von Vitamin E und möglicherweise auch anderer lipophiler Antioxidanzien abhängig von der anatomischen Lokalisation. Diese neuen hautphysiologischen Erkenntnisse sollten beim Design und der Interpretation klinischer Studien zur Überprüfung der Wirksamkeit oraler Antioxidanzien gegenüber oxidativen Stressoren Berücksichtigung finden.

Abstract

Human sebum is produced by sebaceous glands and reaches the skin surface via secretion through the hair shaft. There is experimental evidence that the sebaceous glands and sebum serve as a transport mechanism taking the lipophilic antioxidant vitamin E from the blood to the skin surface. The highest levels of vitamin E are found in the sebum and in the skin lipid film in sebum-rich areas such as facial skin. Recent studies indicate that daily oral supplementation of moderate doses of alpha-tocopherol for at least 3 weeks leads to significant increases of vitamin E levels in human skin sites with a high density of sebaceous glands, such as the face. Thus, the potential photoprotective and antioxidants effects of oral vitamin E, as well as possibly other antioxidants, are site-dependent. These findings should be considered when designing clinical studies to assess the efficacy of oral antioxidants against oxidative stress in the skin.

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Authors and Affiliations

  1. Northwestern University, Chicago, USA

    S. Ekanayake-Mudiyanselage

  2. Department of Dermatology, Boston University Medical Center, Boston, USA

    J. J. Thiele

  3. Department of Dermatology, Boston University Medical Center, 609 Albany Street, Boston, MA 02118, USA

    J. J. Thiele

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  1. S. Ekanayake-Mudiyanselage
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  2. J. J. Thiele
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Correspondence to J. J. Thiele.

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Ekanayake-Mudiyanselage, S., Thiele, J.J. DieTalgdrüse als Transporter für Vitamin E. Hautarzt 57, 291–296 (2006). https://doi.org/10.1007/s00105-005-1090-7

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  • DOI: https://doi.org/10.1007/s00105-005-1090-7

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