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Pathologie neuroendokriner Neoplasien

Pathology of neuroendocrine neoplasms

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Zusammenfassung

In den letzten 5 Jahren wurden durch die European Neuroendocrine Tumor Society (ENETS) grundlegende Empfehlungen für eine standardisierte Pathologiediagnostik und Klassifikation neuroendokriner Neoplasien (NEN) des gastroenteropankreatischen Systems erarbeitet. Diese haben Eingang gefunden in die neue Klassifikation der Tumoren des Verdauungstraktes durch die Weltgesundheitsorganisation (WHO 2010) und teilweise auch in die TNM-Klassifikation der Union for International Cancer Control (UICC 2009). In dieser Übersicht wird die empfohlene Diagnostik hinsichtlich (1) Basisdiagnostik, (2) optionaler klinisch orientierter Diagnostik, (3) proliferationsbasiertem Grading, (4) Nomenklatur und (5) TNM-Klassifikation vorgestellt. Es wird auf die Notwendigkeit der standardisierten Pathologiediagnostik von NEN, erhoben am Biopsat oder Operationspräparat, in Zusammenschau mit den klinisch-bildgebenden Befunden für die optimale Einschätzung der Prognose und die Auswahl tumorspezifischer Behandlungsschemata hingewiesen. Eine enge interdisziplinäre Zusammenarbeit ist hierfür die Voraussetzung.

Abstract

During the last 5 years the European Neuroendocrine Tumor Society (ENETS) has developed basic recommendations for a standardized pathological diagnosis and classification of neuroendocrine neoplasms (NEN) of the gastroenteropancreatic system. These were included in the novel classification of tumors of the digestive system by the World Health Organization (WHO 2010) and the TNM classification of the union for international cancer control (2009). This review presents the pathology diagnosis regarding (1) basic diagnosis, (2) clinically relevant optional diagnosis, (3) proliferation-based grading, (4) nomenclature and (5) TNM classification. It is emphasized that a standardized diagnosis of NEN, together with clinical and radiological findings, is crucial for prognostic stratification and optimal therapy of patients with NEN. Therefore a close interdisciplinary collaboration is essential.

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Authors and Affiliations

  1. Institut für Pathologie, Endokrines Tumorzentrum am Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland

    M. Anlauf & P. Gerlach

  2. Klinik für Endokrinologie, Diabetologie und Rheumatologie, Endokrines Tumorzentrum am Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    M. Schott

  3. Klinik für Allgemein-, Visceral- und Kinderchirurgie, Endokrines Tumorzentrum am Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    A. Raffel, M. Krausch & W.T. Knoefel

  4. Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Deutschland

    M. Pavel

  5. Institut für Pathologie und Konsultationszentrum für Pankreas und Neuroendokrine Tumoren, Klinikum Rechts der Isar, TU München, München, Deutschland

    G. Klöppel

Authors
  1. M. Anlauf
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  2. P. Gerlach
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  3. M. Schott
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  4. A. Raffel
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  5. M. Krausch
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  6. W.T. Knoefel
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  7. M. Pavel
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  8. G. Klöppel
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Correspondence to M. Anlauf.

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Anlauf, M., Gerlach, P., Schott, M. et al. Pathologie neuroendokriner Neoplasien. Chirurg 82, 567–573 (2011). https://doi.org/10.1007/s00104-011-2067-y

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  • DOI: https://doi.org/10.1007/s00104-011-2067-y

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