Zusammenfassung
Peritonealmetastasen sind sekundäre Tumoren des Peritoneums und stellen die häufigste Tumorentität dieser Lokalisation dar. Tumoren, die typischerweise peritoneal metastasieren, sind das Ovarialkarzinom, das kolorektale Karzinom und das Magenkarzinom neben Karzinomen des Pankreas, der Gallenblase, des Uterus und der Lunge. Von den Peritonealmetastasen abzugrenzen sind die seltenen primären malignen Tumoren des Peritoneums wie das primäre maligne peritoneale Mesotheliom oder das primäre peritoneale Karzinom neben benignen Tumoren des Peritoneums sowie nicht neoplastischen, vorwiegend entzündlichen Veränderungen. Eine Differenzierung zwischen einem primären Tumor des Peritoneums und Peritonealmetastasen ist, insbesondere beim CUP („cancer of unknown primary“) -Syndrom, schwierig und gelingt häufig nur mittels immunhistochemischer Zusatzuntersuchungen.
Abstract
Peritoneal metastases are secondary tumours of the peritoneum and the most common tumours at this location. Ovarian carcinoma, colorectal cancer, and gastric cancer are the most frequent ones that show peritoneal involvement, along with carcinomas of the pancreas, gallbladder, uterus, and lung. Primary tumours originating in the peritoneum such as malignant peritoneal mesothelioma, primary peritoneal carcinoma, and benign peritoneal tumours along with inflammatory and reactive lesions must be differentiated from peritoneal metastases. Especially in cancer of unknown primary tumour, the discrimination between primary peritoneal tumours and peritoneal metastases is difficult and often requires immunhistochemical identification.
Literatur
Abbruzzese JL, Abbruzzese MC, Hess KR et al. (1994) Unknown primary carcinoma: natural history and prognostic factors in 657 consecutive patients. J Clin Oncol 12: 1272–1280
Antman KH, Corson JM, Li FP et al. (1983) Malignant mesothelioma following radiation exposure. J Clin Oncol 1: 693–700
Barnetson RJ, Burnett RA, Downie I et al. (2006) Immunhistochemical analysis of peritoneal mesothelioma and primary and secondary carcinoma of peritoneum: antibodies to estrogen and progesterone receptors are useful. Am J Clin Pathol 125: 67–76
Bell DA, Scully RE (1990) Serous borderline tumors of the peritoneum. Am J Surg Pathol 14: 230–239
Biscotti CV, Hart WR (1992) Peritoneal serous micropapillomatosis of low malignant potential (serous borderline tumors of the peritoneum). Am J Surg Pathol 16: 467–475
Churg A, Colby TV, Cagle P et al. (2000) The separation of benign and malignant mesothelial proliferations. Am J Surg Pathol 24: 1183–1200
Clement PB (1994) Diseases of the peritoneum (including endometriosis). In: Kurman RJ (ed) Blaustein‘s pathology of the Female Genital Tract. 4th edn. Springer, New York, pp 647–703
Craig JR, Hart WR (1979) Extragenital adenomatoid tumor: Evidence for the mesothelial theory of origin. Cancer 43: 1678–1681
Dalrymple JC, Russell PBP, Solomon HJ et al. (1989) Extraovarian peritoneal serous papillary carcinoma. A clinicopathological study of 31 cases. Cancer 64: 110–115
Fann JI, Vierra M, Fisher D, Oberhelman HA Jr (1993) Pseudomyxoma peritonei. Surg Gynecol Obstet 177: 441–447
Goldblum J, Hart WR (1995) Localized and diffuse mesotheliomas of the genital tract and peritoneum in women. A clinicopathologic study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, mulitcystic mesotheliomas and localized fibrous tumors. Am J Surg Pathol 19: 1124–1137
Gonzalez-Moreno S, Yan H, Alcorn KW, Sugarbaker PH (2002) Malignant transformation of „beningn“ cystic mesothelioma of the peritoneum. J Surg Oncol 79: 243–251
Gough DB, Donohue JH, Schutt AJ et al. (1994) Long-term patient survival with an aggressive regional approach. Ann Surg 29: 112–119
Kannerstein M, Churg M (1977) Peritoneal mesothelioma. Hum Pathol 8: 83–94
Kerrigan SA, Turnnir RT, Clement PB et al. (2002) Diffuse malignant epithelial mesotheliomas of the peritoneum in woman: a clinicpathologic study of patients. Cancer 94: 378–385
Mayhall FG, Gibbs AR (1991) Malignant peritoneal giving rise to multiple intestinal polyps. Histopathology 20: 47–50
McDonald JC, McDonald AD (1977) Epidemiolgy of mesothelioma from estimated incidence. Prev Med 6: 426–446
Müller H (2006) Die Hyperthermie im Gesamtkonzept der Behandlung des Bauchfellkrebs. DZO 38: 138–140
Muir C (1995) Cancer of unknown primary site. Cancer [Suppl 1] 75: 353–356
Ransom DT, Patel SR, Keeney CL et al. (1990) Papillary serous carcinoma of the peritoneum. A review of 33 cases treated with platin-based chemotherapy. Cancer 66: 1091–1094
Remmele W (1997) Tumoren des Peritoneums. In: Remmele W (Hrsg) Pathologie. Band III, 2. Aufl. Springer, Berlin Heidelberg New York, S 391–480
Riddell RH, Goodman MJ, Moossa AR (1981) Peritoneal malignant mesothelioma in a patient with recurrent peritonitis. Cancer 48: 134–139
Schorge JO, Muto MG, Lee SJ et al. (2000) BRCA-1 related papillary serous carcinoma of the peritoneum has a unique molecular pathogenesis. Cancer Res 60: 1361–1364
Schorge JO, Muto MG, Welch WR et al. (1998) Molecular evidence for multifocal papillary serous carcinoma of the peritoneum in patients with germline BRCA-1 mutations. J Natl Cancer Inst 90: 841–845
Shanks JH, Harris M, Banerjee SS et al. (2000) Mesotheliomas with deciduoid morphology: a morphologic spectrum and a variant not confined to young femals. Am J Surg Pathol 24: 285–294
Steffen HM, Wamnbach G, Hoffmann A et al. (1989) Diagnostik und Therapie des malignen peritonealen Mesothelioms. Med Klin 84: 469–473
Thor AD, Young RH, Clement PB (1991) Pathology of the Fallopian tube, broad ligamentum, peritoneum and pelvic soft tissue. Hum Pathol 22: 856–867
Truong LD, Maccato ML, Awalt H et al. (1990) Serous surface carcinoma of the peritoneum: a clinicpathologic study of 22 cases. Hum Pathol 21: 91–110
Van Ruth S, Achermann YIZ, Van de Vijver MJ et al. (2003) Pseudomyxoma peritonei: a review of 62 cases. Eur J Surg Oncol 29: 682–688
Weiss SW, Tavassoli FA (1988) Multicystic mesothelioma. An analysis of pathologic findings and biologic behaviour in 37 cases. Am J Surg Pathol 12: 737–746
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tischoff, I., Tannapfel , A. Peritonealmetastasen in der pathologisch-anatomischen Befundung. Chirurg 78, 1085–1090 (2007). https://doi.org/10.1007/s00104-007-1427-0
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00104-007-1427-0
Schlüsselwörter
- Peritonealmetastasen
- Peritoneales Mesotheliom
- Primäres peritoneales Karzinom
- Tumorerkrankung mit unbekanntem Primärtumor
- Immunhistochemie