Skip to main content

Advertisement

Log in

Bluthochdruck bei Adipositas im Kindes- und Jugendalter

High blood pressure in obese children and adolescents

  • Leitthema
  • Published:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Adipositas ist auch bei Kindern und Jugendlichen ein bedeutsamer Risikofaktor für eine „essentielle“ Hypertonie, und anders als früher angenommen, hinterlässt der hohe Blutdruck auch schon bei ihnen messbare Schäden am Herz-Kreislauf-System. Wie bei Erwachsenen führt der erhöhte Blutdruck zur Herzvergrößerung, Verkalkung der Herzkranzgefäße und Verdickung der Wände kleiner Gefäße. Die Schädigung ist vor allem dann zu beobachten, wenn Adipositas und andere Risikofaktoren wie erhöhte Blutfette, Hyperinsulinämie und Rauchen hinzukommen. Wie bei jedem Kind mit erhöhtem Blutdruck, muss die Diagnostik die chronische Hypertonie bestätigen, die Ursache der zugrunde liegenden Ursache klären und untersuchen, ob Zielorgane geschädigt sind. Neue Referenzwerte für die Gelegenheitsblutdruckmessung wurden kürzlich in einer repräsentativen Bevölkerungsstudie in Deutschland erhoben. Die Behandlung sollte mit Veränderungen des Lebensstils beginnen, aber oft wird auch eine Behandlung mit Antihypertensiva nötig. Bluthochdruck ist bei Jugendlichen mit Adipositas nicht selten und muss adäquat diagnostiziert und behandelt werden.

Abstract

Obesity is also an important risk factor in children and adolescents for “essential” arterial hypertension, and contrary to what was assumed earlier, high blood pressure does cause damage to the cardiovascular system. As known from adults, elevated blood pressure induces cardiac hypertrophy, calcifications and atherosclerosis at the coronary vessels and thickens the small blood vessels. These early vascular alterations are particularly pronounced, when increased blood pressure is accompanied by other risk factors, such as dyslipidemia, hyperinsulinemia or smoking. As in any child with elevated blood pressure, the diagnostic evaluation should focus on confirmation of hypertension, determine if an underlying cause can be identified and whether hypertensive target organ damage is present. New reference office blood pressure values were recently published by a large representative community-based study in Germany. Therapy should begin with lifestyle modifications; however, antihypertensive medications will often be needed. Hypertension in obese adolescents occurs frequently and must be diagnosed and treated adequately.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Berenson GS, Srinivasan SR, Bao WH et al (1998) Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. N Engl J Med 338:1650–1656

    Article  PubMed  CAS  Google Scholar 

  2. Hanevold C, Waller J, Daniels S et al (2004) The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association. Pediatrics 113:328–333

    Article  PubMed  Google Scholar 

  3. Hansen ML, Gunn PW, Kaelber DC (2007) Underdiagnosis of hypertension in children and adolescents. JAMA 298:874–879

    Article  PubMed  CAS  Google Scholar 

  4. He Q, Ding ZY, Fong DY, Karlberg J (2000) Blood pressure is associated with body mass index in both normal and obese children. Hypertension 36:165–170

    Article  PubMed  CAS  Google Scholar 

  5. Wirth A (2004) Hypertonie beim metabolischen Syndrom. In: Rosenthal J, Kolloch R (Hrsg) Arterielle Hypertonie. Springer, Heidelberg, S 200–205

  6. Lettgen B, Wagner S, Hanze J et al (1994) Elevated plasma concentration of neuropeptide Y in adolescents with primary hypertension. J Hum Hypertens 8:345–349

    PubMed  CAS  Google Scholar 

  7. Sorof JM, Poffenbarger T, Franco K et al (2002) Isolated systolic hypertension, obesity, and hyperkinetic hemodynamic states in children. J Pediatr 140:660–666

    Article  PubMed  Google Scholar 

  8. Sun SS, Grave GD, Siervogel RM et al (2007) Systolic blood pressure in childhood predicts hypertension and metabolic syndrome later in life. Pediatrics 119:237–246

    Article  PubMed  Google Scholar 

  9. Genovesi S, Brambilla P, Giussani M et al (2012) Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. J Hypertens 30:327–335

    Article  PubMed  CAS  Google Scholar 

  10. Rocchini AP, Key J, Bondie D et al (1989) The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N Engl J Med 321:580–585

    Article  PubMed  CAS  Google Scholar 

  11. Flechtner-Mors M, Thamm M, Rosario A et al (2011) Hypertonie, Dyslipoproteinämie und BMI-Kategorie charakterisieren das kardiovaskuläre Risiko bei übergewichtigen oder adipösen Kindern und Jugendlichen: Daten der BZgA-Beobachtungsstudie (EvAKuJ-Projekt) und der KiGGS-Studie Hypertension, Dyslipoproteinemia and BMI-Category Characterise the Cardiovascular Risk in Overweight or Obese Children and Adolescents: Data of the BZgA-Observational Study (EvAKu-J-Project) and the KiGGS-Study. Klin Padiatr 223:445–449

    Article  PubMed  CAS  Google Scholar 

  12. Lurbe E, Cifkova R, Cruickshank JK et al (2009) Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension. J Hypertens 27:1719–1742

    Article  PubMed  CAS  Google Scholar 

  13. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576

    Article  Google Scholar 

  14. Neuhauser H, Thamm M (2007) Blutdruckmessung im Kinder-und Jugendgesundheitssurvey (KiGGS). Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 50:728–735

    Article  CAS  Google Scholar 

  15. Falkner B, Daniels SR (2004) Summary of the fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Hypertension 44:387–388

    Article  PubMed  CAS  Google Scholar 

  16. De Man SA, André JL, Bachmann H et al (1991) Blood pressure in childhood: pooled findings of six European studies. J Hypertens 9:109

    Article  Google Scholar 

  17. Neuhauser HK, Thamm M, Ellert U et al (2011) Blood pressure percentiles by age and height from nonoverweight children and adolescents in Germany. Pediatrics 127:e978–e988

    Article  PubMed  Google Scholar 

  18. Soergel M, Kirschstein M, Busch C et al (1997) Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects. J Pediatr 130:178–184

    Article  PubMed  CAS  Google Scholar 

  19. Kampmann C, Wiethoff C, Wenzel A et al (2000) Normal values of M mode echocardiographic measurements of more than 2000 healthy infants and children in central Europe. Heart 83:667–672

    Article  PubMed  CAS  Google Scholar 

  20. Litwin M, Sladowska J, Antoniewicz J et al (2007) Metabolic abnormalities, insulin resistance, and metabolic syndrome in children with primary hypertension. Am J Hypertens 20:875–882

    Article  PubMed  CAS  Google Scholar 

  21. Böhm M, Reil JC, Danchin N et al (2008) Association of heart rate with microalbuminuria in cardiovascular risk patients: data from I-SEARCH. J Hypertens 26:18–25

    Article  PubMed  Google Scholar 

  22. Kiess W, Sergejev E, Körner A, Hebebrand J (2011) Ist eine Therapie der Adipositas im Kindes-und Jugendalter überhaupt möglich? Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 54:527–532

    Article  CAS  Google Scholar 

  23. Alff F, Markert J, Zschaler S et al (2012) Reasons for (non) participating in a telephone-based intervention program for families with overweight children. PloS One 7:e34580

    Article  PubMed  CAS  Google Scholar 

  24. Shahinfar S, Cano F, Soffer BA et al (2005) A double-blind, dose-response study of losartan in hypertensive children. Am J Hypertens 18:183–190

    Article  PubMed  CAS  Google Scholar 

  25. Pischon T, Sharma AM (2001) Use of beta-blockers in obesity hypertension: potential role of weight gain. Obes Rev 2:275–280

    Article  PubMed  CAS  Google Scholar 

  26. Flynn JT, Smoyer WE, Bunchman TE (2000) Treatment of hypertensive children with amlodipine. Am J Hypertens 13:1061–1066

    Article  PubMed  CAS  Google Scholar 

  27. Rascher W (2005) The hypertensive child. In: Davison A, Cameron J, Grünfeld J et al (Hrsg) Oxford textbook of clinical nephrology. Oxford University Press, Oxford, S 1415–1431

Download references

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to W. Rascher.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rascher, W., Kiess, W. & Körner, A. Bluthochdruck bei Adipositas im Kindes- und Jugendalter. Bundesgesundheitsbl. 56, 492–499 (2013). https://doi.org/10.1007/s00103-012-1638-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00103-012-1638-5

Schlüsselwörter

Keywords

Navigation