Abstract
Two new lanostane triterpenes named ganoderic acid AW1 (1) and ganoderic acid AW2 (2) were isolated from the fungal fruiting bodies of the cultivated new isolate of the Egyptian Ganoderma sp in addition to the known compounds ganomycine A (3), pinellic acid (4), and ergosterol peroxide (5). Their structures were elucidated by detailed analysis of their 1D and 2D-NMR data, as well as high-resolution mass spectroscopy. Ganoderic acid AW1 (1) showed good antimalarial activity against the chloroquine sensitive strain of Plasmodium falciparum with an IC50 value of 257.8 nM with no cytotoxicity up to the concentration of 9 μM.
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Acknowledgements
We would like to thank Dr Shabana Khan, The National Center for Natural Products Research, The University of Mississippi for the antimalarial and antibacterial activities. We also would like to thank Dr Neil Kelleher, Chemistry Department, Northwestern University, Evanston for the generous NMR analyses. We would like to thank Dr. Mohamed Helal and Dr. Khaled ElOkely for thier help with ECD calculations.
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Wahba, A.E., El-Sayed, A.K.A., El-Falal, A.A. et al. New antimalarial lanostane triterpenes from a new isolate of Egyptian Ganoderma species. Med Chem Res 28, 2246–2251 (2019). https://doi.org/10.1007/s00044-019-02450-1
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DOI: https://doi.org/10.1007/s00044-019-02450-1